Results 241 to 250 of about 24,842,000 (395)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

A conceptual model for handling personalized hierarchies in multidimensional databases

, 2009
Yoann Pitarch, Anne Laurent, Pascal Poncelet   +2 more
openalex   +2 more sources

The Role of Food Consumption in the Global Syndemic: A Scoping Review and Conceptual Model. [PDF]

Int J Environ Res Public Health
Garrido G, Severo FC, Bonfim SMV, Dias LF, Domingos ALG, Jones AD, Saraiva AM, Marchioni DML, Junior EV, Ribeiro EMS, Jolliet O, Sarti FM, de Carvalho AM.   +12 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Cyber resilience conceptual model for European Union NIS2 standards implementation in Slovakia. [PDF]

Sci Rep
Ristvej J, Tonhauser M, Chovanec D, Kubás J, Kollár B, Zamiar Z.   +5 more
europepmc   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Holistic Model for SMEs Growth Studies: A Conceptual Overview

, 2015
Johan Krisnanto Runtuk, Budisantoso Wirjodirdjo, Iwan Vanany   +2 more
openalex   +2 more sources

A conceptual model for assessing the risk of unidentified pain. [PDF]

J Pain
Boon JT, Failla MD, Anderson AR, Melnyk BM, Bruehl S, Von Ah D, Muench U, McElfresh J, Carter M, Monroe TB.   +9 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Fog Computing Conceptual Model

, 2018
M. Iorga, Larry Feldman, Robert Barton, Michael J. Martin, Nedim S. Goren, C. Mahmoudi   +5 more
semanticscholar   +1 more source