Results 121 to 130 of about 366,121 (313)

When conceptual models collide: aggregates in IFLA's Library Reference Model [PDF]

, 2019
IFLA’s Library Reference Model defines manifestations as sets of carriers sharing relevant physical and intentional properties, and aggregates as manifestations that embody multiple expressions.
Dubin, David, Jett, Jacob
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Individual variation in undergraduate student metacognitive monitoring and error detection during biology model evaluation

Frontiers in Education
IntroductionModels are a primary mode of science communication and preparing university students to evaluate models will allow students to better construct models and predict phenomena.
Joseph Dauer, Mei Grace Behrendt, McKenna Elliott, Bethany Gettings, Tammy Long, Caron Clark   +5 more
doaj   +1 more source

Key characteristics of patient complexity and patient complexity conceptual models/measurement tools: a scoping review protocol. [PDF]

BMJ Open, 2023
Mutai R, Sugiyama Y, Aoki T, Matsushima M.   +3 more
europepmc   +1 more source

Conceptual Model for Design Team toward Website Construction

, 2009
Since mid 1990s internet has been developing rapidly to become the most booming and emerging media in late history and play an important role in living.
H.J. Hu, J. Yen
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Applications of conceptual models from lifecourse epidemiology in ecology and evolutionary biology. [PDF]

Biol Lett, 2022
Laubach ZM, Holekamp KE, Aris IM, Slopen N, Perng W.   +4 more
europepmc   +1 more source

Using formal concept analysis for the verification of process-data matrices in conceptual domain models. [PDF]

One of the first steps in a software engineering process is the elaboration of the conceptual domain model. In this paper, we investigate how Formal Concept Analysis can be used to formally underpin the construction of a conceptual domain model.
Dedene, Guido, Snoeck, Monique, Poelmans, Jonas, Viaene, Stijn   +3 more
core  

Conceptual Modelling of Services.

J. Univers. Comput. Sci., 2012
Conceptual Modelling of ...
Ma, Hui, Schewe, Klaus-Dieter, Thalheim, Bernhard, Wang, Qing (Ms)   +3 more
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source