Results 101 to 110 of about 366,121 (313)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Supply chain integration-performance nexus in emerging & developing economies: a systematic review

Cogent Business & Management
The literature on SCI-performance nexus remains inconclusive and inconsistent. This study analyses the most recent literature aiming to clarify the most important conceptualisations of SCI, identify existing performance measures, and assess the evidence ...
Goitom Abera Baisa, Dante Benjamin Matellini, Ian D. Jenkinson, Chia-Hsun Chang   +3 more
doaj   +1 more source

A 'conceptual models' approach to organisational resilience

, 2010
Gibson and Tarrant discuss the range of inter-dependant factors needed to manage organisational resilience. Over the last few years there has been considerable interest in the idea of resilience across all areas of society.
Tarrant, Michael, Gibson, Carl
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Climate and Human Behavior Studies for Our Warming World: An Introduction to the Models, Methods, and Data

Advances in Archaeological Practice
This article is an introduction and guide to investigating past relationships between climate and human behavior. Improving understanding of these relationships is essential as humanity confronts the challenges of our warming world.
Scott E. Ingram
doaj   +1 more source

Conceptual Design of High-rises with Parametric Methods

, 2007
This paper describes the use of parametric methods in generating conceptual designs of high-rise buildings. We first assess current conceptual design practice at a leading AE firm and illustrate the challenge of satisfying a complex set of requirements ...
V. Gane, J. Haymaker
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Groundwater and Surface Water Interactions in the Highwood River and Sheep River Watersheds: An Integrated Alpine and Non-Alpine Assessment

Hydrology
Groundwater–surface water interactions were investigated in the Highwood River (3952 km2) and Sheep River watersheds (1568 km2), originating in the Rocky Mountains headwaters of the South Saskatchewan River (Alberta, Canada), to improve understanding of ...
Aprami Jaggi, Dayal Wijayarathne, Michael Wendlandt, Tiago A. Morais, Tatiana Sirbu, Andrew Underwood, Paul Eby, John Gibson   +7 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

On conceptual models for information seeking and retrieval research

Information Research: An International Electronic Journal, 2003
There are several kinds of conceptual models for information seeking and retrieval (IS&R). The paper suggests that some models are of a summary type and others more analytic. Such models serve different research purposes. The purpose of this paper is
Kalervo Jarvelin, T.D. Wilson
doaj