Results 101 to 110 of about 8,079,181 (257)

Conceptual Models and Usability

, 2006
The study of conceptual models is both a complex and an important field within the HCI domain. Many of its key principles resulted from research and thinking carried out in the 1980s, arguably in the wake of Norman (1983).
Ritchie Macefield
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Developing Ontological Theories for Conceptual Models using Qualitative Research [PDF]

, 2005
Conceptual modelling is believed to be at the core of the IS discipline. There have been attempts to develop theoretical foundations for conceptual models, in particular ontological models as axiomatic reference systems.
Recker, Jan C.
core  

Investigating the Connection Between Individual Resilience and Organisational Resilience

Systems
Resilience has become a central theme in organisational research, particularly in sectors such as construction that face frequent disruption, complexity, and uncertainty.
M. Mitansha, Regan Potangaroa
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Conceptual Design of High-rises with Parametric Methods

, 2007
This paper describes the use of parametric methods in generating conceptual designs of high-rise buildings. We first assess current conceptual design practice at a leading AE firm and illustrate the challenge of satisfying a complex set of requirements ...
V. Gane, J. Haymaker
core  

Individual variation in undergraduate student metacognitive monitoring and error detection during biology model evaluation

Frontiers in Education
IntroductionModels are a primary mode of science communication and preparing university students to evaluate models will allow students to better construct models and predict phenomena.
Joseph Dauer, Mei Grace Behrendt, McKenna Elliott, Bethany Gettings, Tammy Long, Caron Clark   +5 more
doaj   +1 more source

COVID-19 and contact tracing apps: The importance of theory and conceptual models. [PDF]

Int J Med Inform, 2023
Jannati N.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Supporting electronic collaboration in conceptual modeling [PDF]

, 2008
We study collaborative modeling by analyzing conversations and loud thinking during modeling sessions and the resulting models themselves. We identify the basic activities of the modeling teams on the social, pragmatic, semantic and syntactic levels and ...
Rittgen, Peter
core