Results 91 to 100 of about 1,910,103 (290)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
HydrologyGroundwater–surface water interactions were investigated in the Highwood River (3952 km2) and Sheep River watersheds (1568 km2), originating in the Rocky Mountains headwaters of the South Saskatchewan River (Alberta, Canada), to improve understanding of ...
Aprami Jaggi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
On conceptual models for information seeking and retrieval research
Information Research: An International Electronic Journal, 2003 There are several kinds of conceptual models for information seeking and retrieval (IS&R). The paper suggests that some models are of a summary type and others more analytic. Such models serve different research purposes. The purpose of this paper is
Kalervo Jarvelin, T.D. Wilson
doaj
Conceptual Models for Intangible Art
Mimesis Journal, 2014 Formal ontologies have been fruitfully employed to describe and document cultural heritage with the twofold goals of providing explicit and shared conceptual models of cultural heritage and of making documentation directly available to men and machines ...
Antonio Lieto +2 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
MISCO: A Conceptual Model for MIS Implementation in SMEs
Information Research: An International Electronic Journal, 1999 Information Technology ('IT') has made a prolific impact, both in sociological and commercial terms. In the business world, the pursuit of new technology and working practices has often been at the expense of equal regard for the correct methods to ...
R.Bali, G.Cockerham, C.Bloor
doaj
Frontiers in Sustainable CitiesThe rapid urbanization and population growth in Kenya highlight the need to revive the National Addressing System (NAS). This study aims to examine address systems across the globe, focusing on countries known for their efficient addressing ...
Isaac Kipkemoi, Innocent Osoro Ngare
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source