Results 91 to 100 of about 8,079,181 (257)
HydrologyGroundwater–surface water interactions were investigated in the Highwood River (3952 km2) and Sheep River watersheds (1568 km2), originating in the Rocky Mountains headwaters of the South Saskatchewan River (Alberta, Canada), to improve understanding of ...
Aprami Jaggi +7 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
MISCO: A Conceptual Model for MIS Implementation in SMEs
Information Research: An International Electronic Journal, 1999 Information Technology ('IT') has made a prolific impact, both in sociological and commercial terms. In the business world, the pursuit of new technology and working practices has often been at the expense of equal regard for the correct methods to ...
R.Bali, G.Cockerham, C.Bloor
doaj
Conceptual Models for Intangible Art
Mimesis Journal, 2014 Formal ontologies have been fruitfully employed to describe and document cultural heritage with the twofold goals of providing explicit and shared conceptual models of cultural heritage and of making documentation directly available to men and machines ...
Antonio Lieto +2 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Frontiers in Sustainable CitiesThe rapid urbanization and population growth in Kenya highlight the need to revive the National Addressing System (NAS). This study aims to examine address systems across the globe, focusing on countries known for their efficient addressing ...
Isaac Kipkemoi, Innocent Osoro Ngare
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A visual language for the collaborative visualization of integrated conceptual models in product development scenarios [PDF]
, 2013 In various industrial and scientific fields, conceptual models are derived from real world problem spaces to understand and communicate containing entities and coherencies.
Brown, Ross A. +2 more
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