Results 71 to 80 of about 8,079,181 (257)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2020 As part of her introduction to ontology enginering, <sup> 1 </sup> Prof. Maria Keet has a slide depicting ontology as a layer apart from conceptual data models: <em> Conceptual data models vs. ontologies.
Donald Winston
core +1 more source
What is a Library Website, Anyway? Reconsidering Dominant Conceptual Models
Partnership: The Canadian Journal of Library and Information Practice and Research, 2021 In late 2019, Thompson Rivers University embarked on a multi-phase website usability project beginning with a website user survey, to be followed shortly afterward by usability testing and interviews.
Amy Paterson
doaj
mSystems, 2019 Accurate predictions across multiple fields of microbiome research have far-reaching benefits to society, but there are few widely accepted quantitative tools to make accurate predictions about microbial communities and their functions.
Eric Sakowski +29 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
VISUAL MODELS OF SYSTEMS ENGINEERING OF ADDITIVE MANUFACTURING PROCESSES
Надежность и качество сложных системBackground. The paper discusses methods for using visual systems engineering tools using the example of additive manufacturing processes. Materials and methods.
A.I. Vlasov, G.A. Volkov, K.V. Selivanov
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Near real-time collaborative conceptual modeling on the web
, 2022 S.344-357Collaboration during the creation of conceptual models is an integral pillar of design processes in many disciplines. Synchronous collaboration, in particular, has received little attention in the conceptual modeling literature so far. There are
Derntl, Michael +4 more
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source