Results 71 to 80 of about 1,910,103 (290)

An Object-Oriented Framework for Explicit-State Model Checking [PDF]

open access: yes, 2007
This paper presents a conceptual architecture for an object-oriented framework to support the development of formal verification tools (i.e. model checkers).
Kattenbelt, M., Rensink, A., Ruys, T.C.
core   +2 more sources

Biogeochemical Interactions In The Application Of Biotechnological Strategies To Marine Sediments Contaminated With Metals

open access: yesNova Biotechnologica et Chimica, 2015
Sediment contamination in coastal areas with high anthropogenic pressure is a widespread environmental problem. Metal contaminants are of particular concern, since they are persistent and cannot be degraded. Microorganisms can influence metal mobility in
Fonti Viviana   +2 more
doaj   +1 more source

A formal theory of conceptual modeling universals [PDF]

open access: yes, 2004
Conceptual Modeling is a discipline of great relevance to several areas in Computer Science. In a series of papers [1,2,3] we have been using the General Ontological Language (GOL) and its underlying upper level ontology, proposed in [4,5], to evaluate ...
Guizzardi, Giancarlo   +2 more
core   +3 more sources

Conceptual modelling: framework, principles, and future research [PDF]

open access: yes, 2007
The conceptual modelling task in a simulation project is very important and yet is still generally regarded as more of an art than a science. The meaning and nature of conceptual modelling are discussed and a framework set out.
Brooks, R J
core  

Using conceptual metaphor and functional grammar to explore how language used in physics affects student learning

open access: yes, 2007
This paper introduces a theory about the role of language in learning physics. The theory is developed in the context of physics students' and physicists' talking and writing about the subject of quantum mechanics.
A. B. Arons   +30 more
core   +5 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Oscillations, metastability and phase transitions in brain and models of cognition [PDF]

open access: yes, 2006
Neuroscience is being practiced in many different forms and at many different organizational levels of the Nervous System. Which of these levels and associated conceptual frameworks is most informative for elucidating the association of neural processes
Werner, MD Gerhard
core  

Current State of and Future Opportunities for Prediction in Microbiome Research: Report from the Mid-Atlantic Microbiome Meet-up in Baltimore on 9 January 2019

open access: yesmSystems, 2019
Accurate predictions across multiple fields of microbiome research have far-reaching benefits to society, but there are few widely accepted quantitative tools to make accurate predictions about microbial communities and their functions.
Eric Sakowski   +29 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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