Results 61 to 70 of about 8,079,181 (257)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Incorporating business requirements and constraints in database conceptual models
, 2004 Entity relationship (ER) approach is predominantly used for conceptual modelling of database systems in terms of entities and their relationships. The approach does not provide sufficient support for incorporating business constraints and their impact on
Khan, Khaled M. +2 more
core
Simulating interactions between saturated and unsaturated storage in a conceptual runoff model [PDF]
, 2003 There is an increasing demand for modelling the fluxes of chemical constituents at the catchment scale. Conceptual runoff models provide a basis for such modelling tasks provided that they capture the essential hydrological processes.
Bishop, Kevin +2 more
core +2 more sources
Development and application of a rainfall-runoff model for semi-arid regions
RBRH, 2020 Despite the advances undertaken in recent years, modeling watershed’s hydrological responses remains a complex task, especially in data-scarce areas. In order to overcome this, new models with distinct representations of hydrological processes continue ...
José Almir Cirilo +5 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
From conceptual models to constrained web forms
, 2002 Constraints expressed within document definitions, data models, ontologies, and domain models, are a key constituent of the Semantic Web. Indeed, Semantic Web applications will rely on these constraints when reasoning about Web contents. This paper deals
Dumas, M. Marlon +2 more
core
A new conceptual design method to support rapid and effective mapping from product design specification to concept design [PDF]
, 2016 Conceptual design has a decisive impact on the product development time, cost and success. This paper presents a new conceptual design method for achieving rapid and effective mapping from product design specification (PDS) to concept design. This method
Li, Rong +5 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Complexity measures for object-oriented conceptual models of an application domain. [PDF]
According to Norman Fenton few work has been done on measuring the complexity of the problems underlying software development. Nonetheless, it is believed that this attribute has a significant impact on software quality and development effort.
Dedene, Guido, Poels, Geert
core
Groundwater conceptual models: implications for evaluating diffuse pollution mitigation measures [PDF]
, 2014 The Water Framework Directive (WFD) identifies diffuse pollution as a long-term threat to water quality. Farming contributes significantly to this pollution. There is a clear need for mitigation measures and assessment of their efficacy.
Newell, A. J. +10 more
core +1 more source