Results 41 to 50 of about 8,079,181 (257)

Il nuovo modello concettuale dell’universo bibliografico: FRBR Library Reference Model

AIB Studi, 2016
Il dibattito su FRBR library reference model qui esposto è basato sul testo 2016 destinato alla worldwide review. Si mettono in evidenza alcuni aspetti innovativi di FRBR-LRM rispetto ai precedenti modelli della famiglia FRBR e si espongono alcune ...
Pat Riva
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

From Conceptual Models to Knowledge Graphs: A Generic Model Transformation Platform

, 2021
Semantic processing of conceptual models is a focus of research since several years, bridging the disciplines of knowledge-based systems, conceptual modeling, and model-driven software engineering.
Muhamed Smajevic, Dominik Bork, Bork, Dominik, Smajevic, Muhamed   +3 more
core   +1 more source

A Systems Thinking Approach to Integrated STEM in School-Based Agricultural Education

Education Sciences
The content and career cluster of agriculture, food, and natural resources (AFNR) provides opportunities for K-12 teachers to engage students to solve complex authentic problems that blend science, technology, engineering, and mathematics (STEM), yet ...
Neil A. Knobloch, Christopher J. Eck, Aaron J. McKim, Hui-Hui Wang   +3 more
doaj   +1 more source

Identifiers within conceptual models and standards

JLIS.it, 2022
Identifiers are numeric or alphanumeric strings of characters permanently and uniquely associated with a resource to ensure stable access to it and its metadata. They play a fundamental role in the semantic web as they guarantee interoperability between
Laura Manzoni
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A participative and facilitative conceptual modelling framework for discrete event simulation studies in healthcare [PDF]

, 2013
Existing approaches to conceptual modelling (CM) in discrete-event simulation do not formally support the participation of a group of stakeholders. Simulation in healthcare can benefit from stakeholder participation as it makes possible to share multiple
Tako, A.A., Kotiadis, K, Vasilakis, C, Tako, A., Tako, A. A., Kotiadis, K., Tako, A A, Kotiadis, Kathy, Vasilakis, C.   +8 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source