Results 41 to 50 of about 366,121 (313)
A conceptual model for megaprogramming [PDF]
ACM SIGSOFT Software Engineering Notes, 1991 " Currently, software is put together one statement at a time. What we need is to put software together one component at a time ." --- Barry Boehm, at the Domain Specific Software Architecture (DSSA) Workshop, July 11--12, 1990.Megaprogramming, as defined at the first ISTO Software Technology Community Meeting, June
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Groundwater conceptual models: implications for evaluating diffuse pollution mitigation measures [PDF]
, 2014 The Water Framework Directive (WFD) identifies diffuse pollution as a long-term threat to water quality. Farming contributes significantly to this pollution. There is a clear need for mitigation measures and assessment of their efficacy.
Newell, A. J. +10 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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Frontiers in Psychology, 2019 In this paper, we present a novel context-dependent approach to modeling word meaning, and apply it to the modeling of metaphor. In distributional semantic approaches, words are represented as points in a high dimensional space generated from co ...
Stephen McGregor +6 more
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JLIS.it, 2022 The paper presents an analysis of user tasks in the conceptual models, with an overview of the objectives and functions of the catalogue from Cutter to the International Cataloguing Principles, a critical reflection on user tasks and a proposal for a ...
Lucia Sardo
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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AlgorithmsLimited understanding exists regarding the methodologies behind designing interfaces for low-income contexts, despite acknowledging their potential value.
Yann Méhat +3 more
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