Results 41 to 50 of about 2,129,612 (296)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Exploring Consumer Collecting Behavior: A Conceptual Model and Research Agenda [PDF]

open access: yes, 2018
Purpose The purpose of this paper is to explore the behaviors that revolve around collecting, the motivations behind these behaviors and the psychological benefits collectors receive from engaging in these collecting behaviors.
Spaid, Brian I.
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Consumer Online Buying Behavior on Social Media Platform in Malaysia: A Conceptual Paper

open access: yesJournal of International Business, Economics and Entrepreneurship
The increased utilisation of social media platforms has been observed to influence consumer behaviour, particularly in online shopping context. This study aims to propose a conceptual framework regarding the factors influencing customer online buying ...
Farhan Nadia Bakly   +3 more
doaj   +3 more sources

Determinants of Turnover Intention in the Private Universities in Malaysia: A Conceptual Paper

open access: yesSHS Web of Conferences, 2018
Turnover intentions in academic institutions has become one of the main concern of the management as surviving and achieving excellence is very much about having the knowledgeable and committed employee.
Ainer Chitra Devi   +2 more
doaj   +1 more source

Monitoring Conceptual Development: Design Considerations of a Formative Feedback tool [PDF]

open access: yes, 2010
This paper presents the design considerations of a tool aiming at providing formative feedback. The tool uses Latent Semantic Analysis, to automatically generate reference models and provide learners a means to compare their conceptual development ...
Berlanga, Adriana J.   +3 more
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

IDC theory: interest and the interest loop

open access: yesResearch and Practice in Technology Enhanced Learning, 2020
Numerous studies have shown that learning is enhanced when students show interest in the subject matter. However, educators continue to grapple with the challenges, or simply do not recognize their potential roles, in the development of students ...
Lung-Hsiang Wong   +7 more
doaj   +1 more source

Model-driven design, simulation and implementation of service compositions in COSMO [PDF]

open access: yes, 2009
The success of software development projects to a large extent depends on the quality of the models that are produced in the development process, which in turn depends on the conceptual and practical support that is available for modelling, design and ...
Dirgahayu, Teduh   +2 more
core   +3 more sources

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