Results 51 to 60 of about 2,129,612 (296)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Translating EU civil protection in the Nordic states – towards a theoretical understanding of the creation of European crisis management capacities. [PDF]
, 2007 This paper analyses how EU civil protection is translated (both in a linguistic/conceptual sense and in an organisational sense) in the Nordic states. The analysis builds on interviews with civil servants and illustrates how European crisis management ...
Britz, Malena.
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Tadeusz Kotarbiński on God and Religion [PDF]
, 2016 The aim of the paper is the presentation of the main reasons of Tadeusz Kotarbiński’s atheism and an interpretation of his position in terms of the conceptual apparatus used in contemporary philosophical debate on atheism.
Łukasiewicz, Dariusz
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Conceptual Paper on Corporate Social Responsibility among Malaysian Entrepreneurs
Sustainable Business and Society in Emerging Economies, 2020 Conflicting views on corporate social responsibility have led to various studies on CSR. However, the previous studies focused mainly on large firms rather than small and medium entrepreneurs.
Tengku Anis Syafiqah Tengku Jasmi +2 more
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Conceptual clustering using relational informatio [PDF]
, 1986 Work in conceptual clustering has focused on creating classes from objects with a fixed set of features, such as color or size. In this paper we describe a system which uses relations between the objects being clustered as well as features of the objects
Nordhausen, Bernd
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Systemic capabilities: the source of IT business value [PDF]
, 2016 Purpose – The purpose of this paper is to develop, and explicate the significance of the need for a systemic conceptual framework for understanding IT business value.
Cadden, Trevor +3 more
core +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Defining Social Engineering in Cybersecurity
IEEE Access, 2020 Social engineering has posed a serious security threat to infrastructure, user, data and operations of cyberspace. Nevertheless, there are many conceptual deficiencies (such as inconsistent conceptual intensions, a vague conceptual boundary, confusing ...
Zuoguang Wang, Limin Sun, Hongsong Zhu
doaj +1 more source