Results 51 to 60 of about 5,453,078 (289)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Conceptual Space for Illiberal Democracy
Politics and GovernanceFor over a decade, populists have been experimenting with a new political regime–illiberal democracy. Vocal proponents, such as Hungary’s PM Viktor Orbán, develop “democratic illiberalism” as an ideational model for the illiberal‐democratic regime they ...
Ruzha Smilova
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Sensory-Motor Grounding of the TIME IS SPACE Conceptual Metaphor
Avances en Psicología Latinoamericana, 2020 Conceptual metaphor theory postulates that interpreting metaphorical expressions requires mentally simulating the base sensory-motor experiences of the conceptual metaphor from which they are derived.
Alejandra Martín +2 more
doaj +1 more source
Grottoes, VA: Conceptual Open Space Master Plan and Entrance Design
, 2022 The Community Design Assistance Center (CDAC) worked with the town of Grottoes to create entryway designs for the primary entries to town as well as Sixth Street, which serves as the town’s “Main Street.” CDAC also prepared an open space master plan ...
Gilboy, Elizabeth +3 more
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Living Inside the UA Space Analog
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core +3 more sources
Learning Conceptual Spaces with Disentangled Facets [PDF]
Proceedings of the 23rd Conference on Computational Natural Language Learning (CoNLL), 2019 Conceptual spaces are geometric representations of meaning that were proposed by G ardenfors (2000). They share many similarities with the vector space embeddings that are commonly used in natural language processing. However, rather than representing entities in a single vector space, conceptual spaces are usually decomposed into several facets, each ...
Rana Alshaikh +2 more
openaire +3 more sources