Results 31 to 40 of about 36,417 (176)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Espaces Mentaux et Intégration Conceptuelle : Retour sur la Constitution de Théories Soeurs
CogniTextes, 2018 This paper is an attempt at describing the origins and the evolution of mental space and conceptual blending theories. The first part depicts the theoretical context in which Fauconnier was immersed, and the kinds of problems his new construct, mental ...
Jean-Michel Fortis et Gilles Col
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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Conceptual Spaces in ViCoS [PDF]
, 2008 We describe ViCoS, a tool for constructing and visualising conceptual spaces in the area of language documentation. ViCoS allows users to enrich existing lexical information about the words of a language with conceptual knowledge. Their work towards language-based, informal ontology building must be supported by easy-to-use workflows and supporting ...
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Postdigital augmented spaces: A conceptual framework
VLC ArquitecturaContemporary augmented spaces are situated in-between digital-analog, material-immaterial, online-offline, and real-virtual binaries. Relatedly, postdigital as a concept suggests that digital technologies are now integrated with almost all aspects of the
Sıla Burcu Başarır, Yüksel Demir
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"Conceptual Space ": an Approach to the Development of Semantic Web [PDF]
بازیابی دانش و نظامهای معنایی, 2017 Semantic Web as the third generation of the Web is due to greater interaction between humans and computers and attempts to understand the processing of information for the machine in order to establish relationships between Web pages in such a way as to ...
Khadijeh Moradi
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A Place Recommendation Approach Using Word Embeddings in Conceptual Spaces
IEEE Access, 2023 The way that computing systems digest geographic space is fundamentally different from people’s understanding of space. In human discourse, a geographic space is referred to by a place name, and the reasoning about a place are based on its ...
Omid R. Abbasi, Ali A. Alesheikh
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