Results 51 to 60 of about 2,525,798 (287)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The application of Conceptual Blending Theory in the Conceptualization of Martyrdom in Resistance Poetry [PDF]
ادبیات پایداری, 2018 Resistance literature is composed of concepts like martyrdom, dedication, Jihad, resistance, and the like, the meaning formation of which has never been analyzed from the semantic aspect of language.
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doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Postdigital augmented spaces: A conceptual framework
VLC ArquitecturaContemporary augmented spaces are situated in-between digital-analog, material-immaterial, online-offline, and real-virtual binaries. Relatedly, postdigital as a concept suggests that digital technologies are now integrated with almost all aspects of the
Sıla Burcu Başarır, Yüksel Demir
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Place Recommendation Approach Using Word Embeddings in Conceptual Spaces
IEEE Access, 2023 The way that computing systems digest geographic space is fundamentally different from people’s understanding of space. In human discourse, a geographic space is referred to by a place name, and the reasoning about a place are based on its ...
Omid R. Abbasi, Ali A. Alesheikh
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Learning Conceptual Spaces with Disentangled Facets [PDF]
Proceedings of the 23rd Conference on Computational Natural Language Learning (CoNLL), 2019 Conceptual spaces are geometric representations of meaning that were proposed by G ardenfors (2000). They share many similarities with the vector space embeddings that are commonly used in natural language processing. However, rather than representing entities in a single vector space, conceptual spaces are usually decomposed into several facets, each ...
Rana Alshaikh +2 more
openaire +3 more sources