Results 61 to 70 of about 2,525,798 (287)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
"Conceptual Space ": an Approach to the Development of Semantic Web [PDF]
بازیابی دانش و نظامهای معنایی, 2017 Semantic Web as the third generation of the Web is due to greater interaction between humans and computers and attempts to understand the processing of information for the machine in order to establish relationships between Web pages in such a way as to ...
Khadijeh Moradi
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Images of Ukraine-EU relations in conceptual metaphors of Ukrainian mass media
Когниция, коммуникация, дискурс, 2018 This paper discusses the system of conceptual metaphors reconstructed via analysis of metaphorical expressions (ME) employed by eight popular Ukrainian newspapers (Holos Ukrainy, Uriadovyi Kurier, Den', Dzerkalo Tyzhnya, Gazeta Po-Ukrains'ky, Segodnya ...
Svitlana Zhabotynska
doaj +1 more source
Linguistik Online, 2020 The study presented in this article investigates the temporal unfolding and multimodal orchestration of meaning in a narration. Two aspects are focused on.
Silva Ladewig, Lena Hotze
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Semantics, conceptual spaces, and the meeting of minds [PDF]
Synthese, 2011 We present an account of semantics that is not construed as a mapping of language to the world but rather as a mapping between individual meaning spaces. The meanings of linguistic entities are established via a “meeting of minds.” The concepts in the minds of communicating individuals are modeled as convex regions in conceptual spaces.
WARGLIEN, Massimo, Peter Gardenfors
openaire +4 more sources
Three levels of naturalistic knowledge [Elektronisk resurs]
, 2019 A recent naturalistic epistemological account suggests that there are three nested basic forms of knowledge: procedural knowledge-how, conceptual knowledge-what, and propositional knowledge-that.
Stephens, Andreas,, Lund University.
core +1 more source
On warehouses, lakes, and spaces. The changing role of conceptual modeling for data integration
, 2022 S.231-245The role of conceptual models, their formalization and implementation as knowledge bases, and the related metadata and metamodel management, has continuously evolved since their inception in the late 1970s. In this paper, we trace this evolution
Jarke, Matthias, Quix, Christoph
core +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source