Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Co-constructing a Conceptual Understanding of System Enactment. [PDF]
Clin Soc Work J, 2022 Morey CM.
europepmc +1 more source
Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett’s oesophagus [PDF]
, 2001 Rhonda F. Souza +2 more
openalex +1 more source
Fora, networks and public examinations: the role and significance of public participation in the new regional plan for South East England [PDF]
, 2001 This paper overviews the main conceptual frameworks for understanding participatory approaches to land use planning and explores their utility in analysing the experience of a recent regional planning exercise in South East England.
Doak, Joe
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Natural Language Understanding: Methodological Conceptualization
PSYCHOLINGUISTICS, 2019 This article contains the results of a theoretical analysis of the phenomenon of natural language understanding (NLU), as a methodological problem. The combination of structural-ontological and informational-psychological approaches provided an opportunity to describe the subject matter field of NLU, as a composite function of the mind, which ...
openaire +4 more sources
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Development and Validation of a Four-Tier Test for the Assessment of Secondary School Students' Conceptual Understanding of Amino Acids, Proteins, and Enzymes. [PDF]
Res Sci Educ, 2023 Putica KB.
europepmc +1 more source
Mathematical thinking of undergraduate students when using three types of software
, 2008 The research investigates how conceptual understanding of mathematics is promoted when using three types of software: black-box (no mathematical intermediate steps shown), glass-box (intermediate steps shown) and open-box (interaction at each ...
Aczel, James +3 more
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, 2012 Unpicking and understanding if and how the web is linked to inequality means: Recognising that the access divide is not over, Thinking beyond hardware, Thinking beyond demographic variables, Developing a conceptual and theoretical toolkit, Beyond ...
Halford, Susan
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source