Results 51 to 60 of about 1,698 (304)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Les vieux maîtres et les jeunes génies
Temporalités, 2011 This paper provides an in-depth review of a book published by the American economist David W. Galenson on the “two cycles of artistic creativity” and their developments in various domains, including science.
Nathalie Heinich
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Non-conceptualism and the Myth of the Given [PDF]
, 2018 Defenders of non-conceptualism have been accused of falling into the Myth of the Given. This is John McDowell's main objection to non-conceptualism. In this article I evaluate some well-known non-conceptualist responses to that objection.
Kalpokas, Daniel Enrique
core +1 more source
Deconstruction/reconstruction of Soviet myth in T. Kibirov’s poem “Love, Komsomol, and Spring”
RUDN Journal of Studies in Literature and JournalismThe article is dedicated to strategies and tactics of engaging with the ‘Soviet text’ in T. Kibirov’s poem “Love, Komsomol, and Spring”. It identifies that the conceptual sphere of the Soviet era, as represented in the poem, was formed as a system of ...
Lyubov G. Kihney
doaj +1 more source
‘Making and remaking history: categorising ‘conceptual art’ in contemporary Chinese art’ [PDF]
Journal of Art Historiography, 2014 During the 1990s, curators and critics embraced conceptual art as a category for legitimizing Chinese art’s global and contemporary status. Conceptual art’s ambiguous parameters, critical cachet, and penchant for destabilization offered unprecedented ...
Peggy Wang
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source