Results 211 to 220 of about 2,746,854 (288)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Using Machine Learning to Analyze the Predictors of Life Satisfaction: Focus on Lifestyle Attitudes and Psychological Factors. [PDF]

Int J Methods Psychiatr Res
Alptekin FB, Torlak E, Asik Ö, Karaaslan B, Turgal E, Burhan HS, Aytac HM, Guclu O.   +7 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Entomophagy in Latin America and its potential for sustainability and food security. [PDF]

Front Nutr
Torres-Acosta RI, Ruiz-De-La-Cruz G, Sinagawa-García SR, Hernández-Trejo A, Hurtado-Noriega C, Gorrín-Armas G, Mendoza-Alatorre M, Pico-Poma JP, Juárez-Aragón MC, Espinoza-Sánchez EA, Gasca-Álvarez HJ, Julián-Chávez B, Sarabia-Guevara DA, Torres-Castillo JA, Benítez-Martínez E, García-García LD.   +15 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Comparative analysis of V ˙ O 2 prediction equations using a novel web-based application: an illustrative example in formerly deployed military veterans. [PDF]

Front Physiol
Alexander T, Falvo MJ, Wilhite DP, Osterholzer JJ, Richmond BW, Cassady SJ, Schneider DJ, Krefft S, Glick DR, Sotolongo AM, Hines SE, Arjomandi M.   +11 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Transforming psychological practice with precision mental health: introduction to the NOVA project. [PDF]

Front Psychol
Roca P, Noheda S, Ramírez-Riveros E, Martín-Azañedo C, Martínez-Zaragoza F, Zangri RM, García Del Valle EP, Sanchez-Pedreño M, León-Garcia M, Gravholt DL, Enrique A, Saunders R, Herrera LJ, Pegalajar MDC, Vázquez C, Rodriguez-Moreno S.   +15 more
europepmc   +1 more source