Results 111 to 120 of about 71,233 (350)

PUBLIC WORKS CONCESSIONS - DELIMITATION FROM OTHER CONTRACTS [PDF]

open access: yesAnnals of the University of Petrosani: Economics, 2012
Initially in France the judicial basis of contracts concerning the occupancy of public domain was the Law of 17 June 1938, but also art. L 84 of the Domain’s Code (1790), as well as a number of relevant decisions of the State Council.
CATALINA-GEORGETA MATEI   +1 more
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

La concesividad como complemento argumental: Pragmática i gramática comparada en asturiano y castellano [PDF]

open access: yesSintagma, 2008
Asturian grammar distinguishes semantic references of mass and individual nouns by means of agreement with adjectives and clitics. But the morphological category of mass neuter in Asturian also develops in utterances a sophisticated specification system ...
Xulio Viejo Fernández
doaj  

Bidding for concessions [PDF]

open access: yes
Privatization of infrastructure ventures in sectors such as energy, telecommunication, transport, and water has become popular over the last decade. Often- for good or bad reasons - private firms are given monopoly franchises under some type of long-term
Klein, Michael
core  

Concession Length and Investment Timing Flexibility [PDF]

open access: yes, 2005
When assigning a concession contract, the regulator faces the issue of setting the concession length. Another key issue is whether or not the concessionare should be allowed to set the timing of new investments. In this paper we investigate the impact of
Dosi, Cesare   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

TRANSACTION COSTS OF THE CONCESSION AGREEMENT AS FORMS OF STATE-PRIVATE PARTNERSHIP

open access: yesВестник университета, 2019
The author of the article investigates the concession mechanism of public-private partnership, as well as transaction costs arising during the implementation of the concession project from the decision of the concluding member to conclude an agreement ...
A. Boldyrev
doaj  

Concessions on Beaches and Concessions on Demand in the new Croatian Law

open access: yesENTRENOVA - ENTerprise REsearch InNOVAtion
In 2023, after a full 20 years, the Republic of Croatia adopted a new legal framework for maritime domain with the enactment of the new Maritime Domain and Seaports Act. The new act addresses numerous technical issues related to Croatia's maritime domain and aligns concessions on maritime domain with the current European legal framework.
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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