Results 141 to 150 of about 71,233 (350)

The Theories of war in practice: possible outcomes and means for the termination of war. Case study: Russian war against Ukraine

Social Development & Security
Purpose: is to anticipate the termination of the Russia-Ukraine war considering the underlying causes on the basis of main war termination theories. Method: comparative analysis, and synthesis.
Khayal Iskandarov, Piotr Gawliczek, Vagif Dadashzade   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Statute şi decizii privind concesiunea de omnibusuri şi fiachere în Comitatul Braşov / Statutes and decisions on the concession on omnibuses and fiacres in the Braşov County

Tyragetia, 2016
Based on the study of documents from the collections of the Braşov County Museum of History, the author provides information on the concession on public transport in the municipalities of the Braşov County at the end of the 19th century.
Cristina Tănase
doaj  

History of concession agreements development in Russia

Вестник университета
The history of concession agreements in Russia spans more than a century, from the late 19th century to the present day. Initially, concessions played a key role in attracting foreign investment and developing infrastructure in the Russian Empire. During
V. Ya. Afanasyev, N. A. Kalyuzhnaya
doaj   +1 more source

Subordinated Public Participation Loans for Financing Motorway concessions in Spain.

, 2008
Budgetary constraints are prompting many governments to encourage private financing of transportation infrastructure through concession contracts. The length and complexity of such contracts often force governments to provide fiscal support in order to ...
Vassallo Magro, José Manuel, Sánchez Soliño, Antonio   +1 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Uvođenje općeg stvarnopravnog režima na objektima lučke suprastrukture izgrađenim na temelju ugovora o koncesiji

Poredbeno Pomorsko Pravo, 2015
U tijeku rasprave o radnom materijalu nacrta prijedloga Zakona o pomorskom dobru i morskim lukama ponovo se aktualiziralo pitanje uspostave općeg stvarnopravnog režima na zgradama i drugim građevinama koje su izgrađene na pomorskom dobru na temelju ...
Loris Rak, Biserka Rukavina, Olga Jelčić   +2 more
doaj  

Tracking without Concessions?

Prolegomena : Časopis za filozofiju, 2013
In the first, shorter part of the paper I point out some problems and potential misunderstandings connected with B. Berčić’s treatment of Nozick’s sensitivity condition for knowledge. In the second part of the paper I offer the condition of modal stability or limited sensitivity as a revision of Nozickian conditions for non-accidental connection ...
openaire   +2 more sources