Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
THE POTENTIAL OF PUBLIC-PRIVATE PARTNERSHIP’S EMPLOYMENT IN URBAN PASSENGER TRANSPORT SPHERE IN OMSK
Authors consider concept of public-private partnership, forms of its implementation. The Legislative acts, regulating the activities public-private partnerships, and features of Russian and foreign application experience are studied. It presents analyses
E. B. Lerman, S. A. Teslova
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Introduction, Purpose. The relevance of the study lies in the fact that the accumulated waste mining production, containing valuable components in industrial quantities, and can be subject to subsoil use, and, therefore, are objects of state ownership ...
O. Malikova, A. M. Maksimova
doaj +1 more source
Parasitism Revealed: On the Absence of Concession [PDF]
An examination of the role of ideologies from the past in shaping educational thought, action, policy and practice in the present. Takes the position that inequality is an expression of a fundamentally parasitic relationship forged during the 17th ...
Winfield, Ann G.
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
L’évolution des politiques de protection et l’intégration du secteur privé dans la conservation
The model of concession was started in Colombia since 2005. This management strategy tries to advantage the territories’ economical development as well as the conservation of heritages.
Mara Sierra Jimenez
doaj +1 more source
ANALYSIS OF CONCESSIONS POTENTIAL IN THE TOURISM INDUSTRY OF THE REPUBLIC OF CRIMEA [PDF]
Н.А. Березина
openalex +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Efficient Methods for Automated Multi-Issue Negotiation: Negotiating over a Two-Part Tariff
In this article, we consider the novel approach of a seller and customer negotiating bilaterally about a two-part tariff, using autonomous software agents.
Gerding, E. H. +2 more
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