Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
TRANSACTION COSTS OF THE CONCESSION AGREEMENT AS FORMS OF STATE-PRIVATE PARTNERSHIP
The author of the article investigates the concession mechanism of public-private partnership, as well as transaction costs arising during the implementation of the concession project from the decision of the concluding member to conclude an agreement ...
A. Boldyrev
doaj
Aspects on Practice of Concession in the Romanian Economy in Inter-War Period [PDF]
The restructuring and modernization of the Romanian economy and society in the interwarperiod imposed to governors, significant efforts, in order to accumulate the capital necessary toachieve the economic objectives.
Popa Florina
doaj
IMPLEMENTATION OF PUBLIC-PRIVATE PARTNER-SHIP PROJECTS IN THE RUSSIAN ARCTIC
The application of public-private partnership to stimulate the socio-economic development of the Arctic zone are considered. The importance of this task is determined by the fact that the reserves of natural resources located in the Arctic should provide
O. Bolshakova, V. Volkova, A. Surnova
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Contract regulation of commercial concession (franchising): problems of civil law development
Objective: to define the systems of legal regulation of commercial congcession (franchising) in the world practice. To reveal the features of commercial concession regulation in Russia.
N. A. Yushchenko, E. F. Gumerova
doaj
PUBLIC WORKS CONCESSIONS - DELIMITATION FROM OTHER CONTRACTS [PDF]
Initially in France the judicial basis of contracts concerning the occupancy of public domain was the Law of 17 June 1938, but also art. L 84 of the Domain’s Code (1790), as well as a number of relevant decisions of the State Council.
CATALINA-GEORGETA MATEI +1 more
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
La concesividad como complemento argumental: Pragmática i gramática comparada en asturiano y castellano [PDF]
Asturian grammar distinguishes semantic references of mass and individual nouns by means of agreement with adjectives and clitics. But the morphological category of mass neuter in Asturian also develops in utterances a sophisticated specification system ...
Xulio Viejo Fernández
doaj
Scientifically based biodiversity management in timber concessions: contribution to conservation and sustainable use of biodiversity [PDF]
During the past 25 years, forest laws in Central African countries have undergone major changes. Management plans were made mandatory: nearly 19 million hectares of timber concessions (38% of total granted concessions) were subject to a management plan ...
Bayol, Nicolas +4 more
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