Results 91 to 100 of about 37,492 (304)
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Bidding for Concessions : The Impact of Contract Design
Infrastructure concession contracts set out the performance obligations and rights of concessionaires and the incentives and risks under which they operate, including pricing arrangements.
Klein, Michael
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Privatization of infrastructure ventures in sectors such as energy, telecommunication, transport, and water has become popular over the last decade. Often- for good or bad reasons - private firms are given monopoly franchises under some type of long-term
Klein, Michael
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The formalization fix? Land titling and land concessions in Cambodia [PDF]
Issuing land titles to smallholder farmers has long been embraced as a way to promote lending and land markets, but is increasingly being reframed as a way to protect smallholders from irresponsible agricultural investment.
Dwyer, Michael B.
core +2 more sources
The concession granted to Russian Company of Koosis Teofeelucktous regarding the utilization of the Caspian forests of Iran and its consequences [PDF]
The present study investigates how the concession for the exploitation of north forests of Iran was submitted to Russian company “Koosis Teofeelucktous” as well as its consequences and effects on the under- utilization forests. For the first time in this
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Causes and Consequences of Government Concessions to Protests [PDF]
Political street protests are a prominent form of political participation worldwide that transcends political regimes and ideologies. When governments give in to protesters' demands and grant concessions, these concessions are often assumed to indicate a
Leuschner, Elena
core +1 more source
Every economic activity of public legal bodies, and similarly with the activities of public-legal bodies in awarding public contracts to business partners, is subject to the rules of market competition.
Damir Aviani
doaj

