Results 71 to 80 of about 292,304 (362)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Inland Ports in the Republic of Croatia: Approvals for Port Activities instead of Concessions
Promet (Zagreb), 2008 According to the 1998 Act on Inland Ports, the right to performall port activities within inland ports of the Republic ofCroatia is given on the basis of concession, obtained throughbidding.
Goran Vojković
doaj +1 more source
Multiple-use forest management in Central Africa: Perceptions, implementation and evolution [PDF]
, 2011 Although multiple-use forest management (MUFM) is supported by forestry laws in the Congo Basin countries, this approach remains confused, misunderstood and little implemented.
Essoungou, Julienne Nadège +1 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Legal nature of the Concession Contract
Zbornik Radova Pravnog Fakulteta u Splitu, 2011 In this paper the authors analyse the legal nature of concession contract after the General Adiministrative Act came into force. Also, the concepts of concession and administrative contract in theory and in legislation are considered.
Marko Šikić, Frane Staničić
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Privatization of infrastructure ventures in sectors such as energy, telecommunication, transport, and water has become popular over the last decade. Often- for good or bad reasons - private firms are given monopoly franchises under some type of long-term
Klein, Michael
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
THE CONCESSION ON MARITIME DOMAIN – THE NOVELTY IN THE CROTIAN LEGISLATION
Zbornik Radova Pravnog Fakulteta u Splitu, 2009 Croatian Maritime Domain and Seaports Act (2003) consists that maritime domain is a public domain of great importance for the Republic Croatia, it is within particular protection and is used according to specific legal conditions. In this article, author
Dragan Bolanča
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