Results 51 to 60 of about 26,070 (266)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Late concessions in bid to secure new drugs strategy.
, 2017 Doubts over the forthcoming launch of the National Drugs Strategy appear to have subsided after community groups secured late concessions in relation to effective implementation structures and actions to tackle alcohol abuse, intimidation and youth ...
O'Keeffe, Cormac
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Bringing OBUs onshore : assessing the concessions
, 1998 In the context of the Federal Government's desire to establish Australia as a competitive international financial centre this article examines the current position of OBUs in Australia.
Sadiq, Kerrie
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
An evaluation of the capital gains tax concessions for small business
, 2006 The small business Capital Gains Tax (CGT) concessions were introduced by the Federal Treasurer on 21 September 1999. The provisions are based on the landmark Review of Business Taxation.
Marriage, Wayne Wilson
core
The OECD Competition Committee debated concessions in February 2006. Governments have long been engaged in providing goods or services to their citizens that could, in some form, be provided by the private sector.
OECD
core +1 more source
, 2022 U ovom završnom radu obrađena je tematika koncesija na zračnim lukama i njihova učinkovitost na cjelokupni zračni promet. Navedene su i objašnjene vrste koncesija, način korištenja, njihov utjecaj i sam razvoj zračnih luka.
Borisavljević, Karlo
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Concessions on Beaches and Concessions on Demand in the new Croatian Law
ENTRENOVA - ENTerprise REsearch InNOVAtionIn 2023, after a full 20 years, the Republic of Croatia adopted a new legal framework for maritime domain with the enactment of the new Maritime Domain and Seaports Act. The new act addresses numerous technical issues related to Croatia's maritime domain and aligns concessions on maritime domain with the current European legal framework.
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source