Results 31 to 40 of about 26,070 (266)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Governance of national parks at the crossroads: New Zealand’s silent reform [PDF]
, 2015 New Zealand’s national parks are major attractions for tourism and recreation, while hosting other commercial activities considered compatible with that primary role, like grazing, commercial filming and renewable electricity production.
Dinica, Valentina, Valentina Dinica
core +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Infrastructure Concessions : To Auction or Not to Auction?
, 1998 Should a conceding authority auction off or negotiate a contract for an exclusive private infrastructure deal? Advocates of negotiation often argue that a formal competition may take too much time, that the
Klein, Michael
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Traffic Risk in toll motorway concessions in Spain: An analysis of the ramp-up period.
, 2008 This paper analyzes the behaviour of actual traffic versus the traffic declared by the concessionaire in its offer in toll motorway concessions in Spain during the first few years of operation (ramp-up period).
Baeza Muñoz, Mª de los Ángeles +1 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The formalization fix? Land titling and land concessions in Cambodia [PDF]
, 2015 Issuing land titles to smallholder farmers has long been embraced as a way to promote lending and land markets, but is increasingly being reframed as a way to protect smallholders from irresponsible agricultural investment.
Dwyer, Michael B.
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Regulating Concessions of Toll Motorways, An Empirical Study on Fixed vs. Variable Term Contracts. [PDF]
Recent theoretical developments on concession contracts for long term infrastructure projects under uncertain demand show the benefits of allowing for flexible term contracts rather than fixing a rigid term.
Daniel Albalate, Germa Bel
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