Results 121 to 130 of about 37,492 (304)
The Social Structure and Ideology of the Rebel Movement in Yakutia during 1921–1922
Ученые записки Казанского университета: Серия Гуманитарные науки, 2017 As part of the complex research on the Yakut anti-Soviet rebel movement in 1921–1922, which rose to the national level, the social structure and ideology of the rebels have been considered.
E.P. Antonov, V.N. Antonova
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Concessions and Protest Demobilization
How and why do concessions, or promises to implement reform in the future, affect protest mobilization in autocracies? Concessions are a routine response to protest and generate a puzzling empirical regularity: Although autocrats often renege once ...
Sasha de Vogel, Jessica S. Sun
core +1 more source
Forest Science and TechnologySustainable forest management in the Peruvian Amazon faces significant challenges due to illegal logging and inadequate control over timber supply chains.
Jorge Birino Alvarez-Melo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Infrastructure concessions in Latin America : government-led renegotiations [PDF]
The authors complement the existing knowledge in the renegotiation literature on infrastructure concessions by analyzing government-led renegotiations.
Laffont, Jean-Jacques +2 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
New legal framework of concessions in Croatia
Zbornik Radova Pravnog Fakulteta u Splitu, 2014 At the end of 2012, Republic of Croatia put into force new Concessions Act, adjusted to the Proposal for a Directive of the European Parliament and of the Council on the award of concession contract from 2011. New Act is an important change on concession
Goran Vojković
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source