Results 141 to 150 of about 37,492 (304)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The Capitalization of Seller Paid Consessions [PDF]
Using a hedonic pricing model, we analyze the capitalization of total seller paid discount points and closing costs into the price of a house. We hypothesize that sellers are concerned about the sales price net of total seller paid concessions (SPNC ...
James R. Webb +2 more
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
The EU's 2014 Concessions Directive
, 2014 Discusses the background and provisions of Directive 2014/23 (Concessions Directive), including its measures on: (1) its scope and its definition of a "concession"; (2) mixed contracts; (3) supply concessions; (4) the duration of concessions; (5) the ...
Craven, Richard
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Zero-deforestation commitments in Indonesia's palm oil sector achieve high compliance but no additionality. [PDF]
Proc Natl Acad Sci U S AStigler M +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The small business CGT concessions: Evidence from the perspective of the tax practitioner
, 2014 On 21 September 1999 Division 152 was inserted into the Income Tax Assessment Act (1997) (ITAA 1997).\ud Division 152 contains the small business CGT concessions, which enables eligible small business taxpayers to\ud reduce the amount of tax payable on ...
Marsden, Stephen J., Sadiq, Kerrie
core
Potential of different area-based governance mechanisms for achieving Global Biodiversity Framework goals. [PDF]
Nat CommunNegret PJ +11 more
europepmc +1 more source