Results 171 to 180 of about 1,610,336 (282)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Favourable mid- to long-term clinical and functional outcomes and low redislocation rates following derotational distal femoral osteotomy for the treatment of recurrent patellofemoral instability. [PDF]

J Exp Orthop
Rab P, Achtnich A, Hinz M, Imhoff FB, Herbst E, Grüning L, Brunner M, Siebenlist S, Vieider RP.   +8 more
europepmc   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Model for concomitant pulmonary embolism in a deep vein thrombosis patient. [PDF]

J Vasc Surg Venous Lymphat Disord
Ahmad S, Ali R.
europepmc   +1 more source

Activity of Some Hepatic Enzymes in Schistosomiasis and Concomitant Alteration of Arylsulfatase B

, 2004
Mahmoud Balbaa, Mohamed A. Elkersh, Hamdy Mansour, Galila A. Yacout, Mohamed Ismail, Ahmed Malky, Khaled Bassiouny, Nihad Abdel-Monem, Kamal Kandeel   +8 more
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Pharmacokinetic Interaction Between Isavuconazole and Rifabutin in a Real-World Setting. [PDF]

Mycoses
Shah S, Clarke L, Lee T, Georgiades L, Smith BJ, Venkataramanan R, Rivosecchi RM.   +6 more
europepmc   +1 more source

The majority of patients with multidrug-resistant tuberculosis in Sub-Saharan Africa present a concomitant resistance to pyrazinamide

, 2016
Géraldine Daneau, Mourad Gumusboga, Pim de Rijk, Arnaud Trébucq, Leen Rigouts, Armand Van Deun, Bouke C. de Jong   +6 more
openalex   +1 more source

Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity [PDF]

, 2011
Sandra J. Shefelbine
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source