Results 241 to 250 of about 1,078,128 (318)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

COnCOmitaNt pulsed field ablation-based pUlmonary vein isolation and lefT atrial appendage closure: the COCONUT study. [PDF]

Europace
Heeger CH, Roten L, Della Rocca D, Velagić V, Gupta D, De Potter T, Sticherling C, Urbanek L, Schmidt B, Parwani AS, Garcia-Bolao I, Arancio R, Nawar A, Mathew S, Beney J, Rolfes H, Sievert K, Boveda S, Lepillier A, Niro M, Wakili R, Steger A, Awada A, Pasara V, Massoullié G, Nekic A, Vanhaverbeke M, Almorad A, Eschalier R, Didenko M, Contarini M, Räber L, Wenzel JP, Rattka M, Scherr D, Tilz RR, Bergmann MW.   +36 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Lipedema-Related Outcomes During Gestrinone Treatment for Estrogen-Dependent Gynecological Disorders: A Real-World Retrospective Case Series. [PDF]

Cureus
Frederichi de Souza P.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Outcomes of Abdominal Panniculectomy With or Without Concomitant Ventral Hernia Repair in a High-risk Cohort. [PDF]

Plast Reconstr Surg Glob Open
Karwoski AS, Jung E, Schlidt K, Rasko YM.   +3 more
europepmc   +1 more source

Inclisiran-induced LDL-cholesterol reduction with and without concomitant statin therapy: a real-world analysis. [PDF]

BMC Cardiovasc Disord
Seidel M, Seibert FS, Anft M, Stervbo U, Babel N, Westhoff TH, Bertram S.   +6 more
europepmc   +1 more source