Results 131 to 140 of about 5,517,215 (329)

Risk of infections in rheumatoid arthritis patients treated with tocilizumab

, 2011
Objectives. To investigate the occurrence and risk factors for infections in RA patients treated with tocilizumab. Methods. A cohort of all RA patients (n = 112) starting tocilizumab therapy between October 2008 and March 2010 in Northern Bavaria was ...
Schuch, Florian, Jürgen Rech, Schett, Georg, Zwerina, Jochen, Nüsslein, Hubert, Karin Manger, Tony, Hans-Peter, Georg Schett, Jochen Zwerina, Bernhard Manger, Florian Schuch, Manger, Bernhard, Rech, Jürgen, Matthias Englbrecht, Manger, Karin, Hans-Peter Tony, Lang, Veronika R., Hubert Nüsslein, Fleck, Martin, Martin Fleck, Veronika R. Lang, Englbrecht, Matthias   +21 more
core   +1 more source

Congenital rubella and cytomegalovirus infection in a new born with unusual hematological features: A case report

MRIMS Journal of Health Sciences, 2016
TORCH infections are unique in their pathogenesis and have potentially devastating clinical manifestations. We present a case of concomitant Rubella and CMV infection in a newborn with unusual hematological and immunological features which ended fatally.
Ramanan Duraiswami, Teena Rajeev
doaj   +1 more source

Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR [PDF]

, 2012
BACKGROUND: Albendazole and mebendazole are increasingly deployed for preventive chemotherapy targeting soil-transmitted helminth (STH) infections. We assessed the efficacy of single oral doses of albendazole (400 mg) and mebendazole (500 mg) for the ...
Sayasone, S., Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong (148913), Jennifer Keiser, Utzinger, Jürg, Vilavanh Xayaseng (189526), Kongsap Akkhavong (148931), Phonepasong Ayé Soukhathammavong, Penelope Vounatsou, Hatz, C., Peter Odermatt, Hatz, Christoph, Somphou Sayasone, Sayasone, Somphou, Vounatsou, P., Phonepasong Ayé Soukhathammavong, Jennifer Keiser (39606), Phongluxa, Khampheng, Jürg Utzinger, Kongsap Akkhavong, Soukhathammavong, Phonepasong Ayé, Xayaseng, Vilavanh, Soukhathammavong, P. A., Xayaseng, V., Odermatt, P., Vilavanh Xayaseng, Utzinger, J., Keiser, J., Jürg Utzinger (39609), Odermatt, Peter, Christoph Hatz (35423), Penelope Vounatsou (49253), Akkhavong, K., Peter Odermatt (148926), Akkhavong, Kongsap, Keiser, Jennifer, Somphou Sayasone (183492), Khampheng Phongluxa (148910), Vounatsou, Penelope, Christoph Hatz, Phongluxa, K., Odermatt Peter, Utzinger Jürg, Vounatsou Penelope, Soukhathammavong Phonepasong Ayé, Phongluxa Khampheng, Akkhavong Kongsap, Xayaseng Vilavanh, Keiser Jennifer, Sayasone Somphou, Hatz Christoph   +50 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Healthcare Associated Infections annual report; Report to the legislature concerning the status of the Healthcare Associated Infections Initiative

, 2008
Annual; Began with Oct. 1, 2008.; Description based on: Oct. 1, 2008; tilte from PDF cover (publisher's web site, viewed May 21, 2009).; At head of title: State of Connecticut.; "An Act Concerning Hospital Acquired Infections."; Latest issue consulted ...
Healthcare Associated Infections Program (Conn.)
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source