Results 71 to 80 of about 679,766 (271)

Rebuilding national unity through discourse in China: strategic narrative and concordance

open access: yesTIPA. Travaux interdisciplinaires sur la parole et le langage, 2017
The purpose of this article is to examine the discursive practices used by the Chinese political leadership in its attempts to rebuild national unity and avoid potential conflict in fostering concordance between three key actors, which are the Party, the
Laura-Anca Parepa
doaj   +1 more source

Integrated cosmological probes: Concordance quantified

open access: yes, 2017
Assessing the consistency of parameter constraints derived from different cosmological probes is an important way to test the validity of the underlying cosmological model. In an earlier work [Nicola et al., 2017], we computed constraints on cosmological
Amara, Adam   +2 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Neutrinos and Future Concordance Cosmologies

open access: yes, 2008
We review the free parameters in the concordance cosmology, and those which might be added to this set as the quality of astrophysical data improves. Most concordance parameters encode information about otherwise unexplored aspects of high energy physics,
Adshead P   +10 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

A Comparison of the Bacterial Culture Results of Maxillary Sinus Mucosa and Pus Collections for Chronic Maxillary Rhinosinusitis

open access: yesSiriraj Medical Journal, 2019
Objective: Although maxillary antral taps are the standard for collecting pus for culture, they sometimes reveal no growth. Intraoperative mucosal cultures are another method to collect pathogen samples.
Anan Bedavanija, M.D.   +4 more
doaj   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks   +10 more
wiley   +1 more source

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