Results 141 to 150 of about 901,954 (313)

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

open access: yesAdvanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui   +9 more
wiley   +1 more source

Characterization of concrete with recycled aggregates produced from returned concrete

open access: yes, 2015
Returned concrete is the residual amount of fresh concrete that is not placed at the job site and returns to the ready-mix plant in the truck mixer. According to local conditions, returned concrete may range from 1 to 5 per cent of the overall concrete ...
Brocchi A.   +6 more
core  

Open time and extrudability performance analysis of 3D printed concrete with recycled concrete fine aggregates using rheological and computer vision techniques [PDF]

open access: yes
This study examines the open time and extrudability performance of 3D-printed concrete elements using recycled concrete fine aggregates (RCFA). It emphasizes the importance of fresh state properties like extrudability and open time, which are crucial for
Raphael, Benny   +4 more
core   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

open access: yesAdvanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li   +15 more
wiley   +1 more source

Strengenthening of concrete bridges using reinforced sprayed concrete under state and fatigue loading.

open access: yes, 1997
PhDThe Department of Transport's bridge assessment programme has revealed that a significant number of bridges are not strong enough to carry the much heavier commercial axle loads that will soon be applied to UK bridges. To address this problem, this
Dung, Pham-Thanh
core  

Time-dependent analysis of continuous precast prestressed concrete beams. [PDF]

open access: yes, 1999
A literature survey on the subject of construction, analysis and design of precast prestressed concrete beams made continuous has been conducted from which various methods of achieving continuity between the precast units have been identified.
Jaafar, Mohd Saleh
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu   +4 more
wiley   +1 more source

Traction Force Microscopy for Viscoelastic Substrates: A Semi‐Analytical Method

open access: yesAdvanced Science, EarlyView.
A semi‐analytical viscoelastic traction force microscopy framework is introduced for quantifying time‐resolved cell tractions on flat finite‐thickness substrates. The method generalizes elastic traction force microscopy to Generalized Maxwell materials, identifies when elastic approximations remain valid and, when they do not, shows that inferred ...
Adrià Villacrosa‐Ribas   +10 more
wiley   +1 more source

A Concrete Lenin in a Concrete Situation

open access: yesStasis, 2016
Book review: Tariq Ali, The Dilemmas of Lenin: Terrorism, War, Empire, Love, Revolution London: Verso, 2017, 384 pp., ISBN ...
openaire   +2 more sources

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