Results 41 to 50 of about 3,635 (261)

Temperature influence on creep of reinforced concrete

open access: yesRevista IBRACON de Estruturas e Materiais, 2020
: The creep of concrete promotes strains over time in structural members kept under sustained load. It causes the stress decrease on the concrete and the steel stress increase in reinforced concrete members. The moisture content and temperature influence
Edmilson Lira Madureira   +1 more
doaj   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

open access: yesAdvanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie   +12 more
wiley   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

open access: yesAdvanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang   +9 more
wiley   +1 more source

Self‐Assembly of Organic–Inorganic Copolymers Toward Bio‐Inspired Cementitious Composites

open access: yesAdvanced Science, EarlyView.
Organic–inorganic copolymerization of calcium silicate hydrate and thioctic acid produces a self‐organized nanocomposite inspired by the disordered collagen–mineral architecture of trabecular bone. The resulting material combines a compressive strength above 300 MPa with intrinsic physical reprocessibility, retaining over 80% of its strength and energy
Zonglin Xie   +8 more
wiley   +1 more source

Prediction of Creep Concrete in Lightweight Concrete with Pumice as Coarse Aggregate

open access: yesRekayasa Sipil
Concrete creep is the additional strain that develops in concrete under constant stress over time. In this study, lightweight concrete is created by entirely replacing coarse aggregate with pumice to reduce the concrete's overall weight.
Chairah Maulidyah   +2 more
doaj   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

open access: yesAdvanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang   +7 more
wiley   +1 more source

Experimental study on creep behavior of high-strength concrete filled steel tubular (HSCFST) columns

open access: yesCase Studies in Construction Materials
The use of High Strength Concrete Filled Steel Tube (HSCFST) members has become widespread, but there is limited research on their creep behavior. This study examines the creep and shrinkage characteristics of HSCFST columns subjected to axial loading by
Yonghui Huang   +4 more
doaj   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

open access: yesAdvanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen   +5 more
wiley   +1 more source

Effect of CNTs and MEA on the creep of face-slab concrete at an early age

open access: yesNanotechnology Reviews, 2022
The creep of face-slab concrete in a rockfill dam is critical for determining the restrained stress and cracking resistance of the concrete at an early age.
Zhao Zhifang   +6 more
doaj   +1 more source

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