Results 61 to 70 of about 30,211 (267)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Quantum steering ellipsoids, extremal physical states and monogamy
New Journal of Physics, 2014 Any two-qubit state can be faithfully represented by a steering ellipsoid inside the Bloch sphere, but not every ellipsoid inside the Bloch sphere corresponds to a two-qubit state.
Antony Milne +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Anuario de Estudios Medievales, 2017 [fr] En 802/1400-803/1401, Tamerlan occupa Damas. Les marchands européens partirent de la Syrie et la nouvelle de cet événement ne tarda pas à circuler dans les principaux centres commerciaux européens semant la panique en perturbant le fonctionnement ...
Pierre Moukarzel
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Revue Marocaine de Recherche en Management et Marketing, 2019 Dans un monde marqué par la globalisation, les alliances stratégiques sont de plus en plus répandues dans différents secteurs d’activités pour faire face aux menaces des concurrents étrangers.
MOHAMED ANIS TAMIRI, MINA ELGRAINI
doaj
Problems of strategic management of processes of modernization of the Russian economy
Путеводитель предпринимателя, 2020 In this article author shows us main goals of strategic management as main mechanism of Russia social and economic development. Author especially points out necessity of space development, overcoming of excessive differentiation, managing conditions of ...
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source