Results 71 to 80 of about 30,211 (267)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Les stars au firmament des destinations

open access: yesTéoros, 2005
Plusieurs destinations gagnent en popularité, deviennent plus accessibles et voient croître substantiellement leurs arrivées touristiques, l’espace de quelques années. Comment se profile la concurrence du Canada ?
Michèle Laliberté
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Le tourisme dans l’espace caribéen

open access: yesTéoros, 2007
Les îles et les rivages de la Caraïbe, destinations exotiques longtemps réservées à quelques élites, s’ouvrent largement au tourisme de masse. La quantification des flux touristiques reste délicate dans l’espace caribéen qui s’est construit à travers des
Olivier DEHOORNE
doaj  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Le patrimoine mondial est-il un mirage économique ?Les enjeux contrastés du développement touristique

open access: yesTéoros, 2011
La Liste du patrimoine mondial de l’UNESCO est réputée reposer sur des principes d’universalité. Cependant, ses contempteurs observent que la multiplication des sites inscrits, puis l’élargissement des catégories de patrimoine, s’accompagnent d’une ...
Lionel Prigent
doaj  

Arbeit und Spiel

open access: yesTr@jectoires, 2012
Cet article met en lumière la relation entre travail et jeu. Après avoir démontré l'opposition historique entre les deux concepts, celle-ci sera remise en question à travers le discours actuel sur la gamification.
Stefan Meißner
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

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