Results 101 to 110 of about 1,886,076 (260)

Evolution of self-maintaining cellular information processing networks [PDF]

open access: yes, 2011
We examine the role of self-maintenance (collective autocatalysis) in the evolution of computational biochemical networks. In primitive proto-cells (lacking separate genetic machinery) self-maintenance is a necessary condition for the direct reproduction
Decraene, James, McMullin, Barry
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Bayesian Based Diagnostic Model for Condition Based Maintenance of Offshore Wind Farms

open access: yesEnergies, 2018
Operation and maintenance costs are a major contributor to the Levelized Cost of Energy for electricity produced by offshore wind and can be significantly reduced if existing corrective actions are performed as efficiently as possible and if future ...
Masoud Asgarpour   +1 more
doaj   +1 more source

Approximating the Randomized Hitting Time Distribution of a Non-stationary Gamma Process [PDF]

open access: yes
The non-stationary gamma process is a non-decreasing stochastic process with independent increments. By this monotonic behavior this stochastic process serves as a natural candidate for modelling time-dependent phenomena such as degradation. In condition-
Frenk, J.B.G., Nicolai, R.P.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Perbandingan Metode Bina Marga dan Metode PCI (Pavement Condition Index) dalam Penilaian Kondisi Perkerasan Jalan (Studi Kasus : Simpang Lago - Simpang Buatan) [PDF]

open access: yes, 2018
There are methods that can be used to evaluate pavement conditions, such as Bina Marga and PCI (Pavement Condition Index) methods. In the Bina Marga method, the determination of road condition values are done by summing numbers and values of damage ...
Copricon, D. E. (Deby)   +2 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Corrosion Sensor Development for Condition-Based Maintenance of Aircraft

open access: yesInternational Journal of Aerospace Engineering, 2012
Aircraft routinely operate in atmospheric environments that, over time, will impact their structural integrity. Material protection and selection schemes notwithstanding, recurrent exposure to chlorides, pollution, temperature gradients, and moisture ...
Gino Rinaldi   +5 more
doaj   +1 more source

Overview of predictive condition based maintenance research using bibliometric indicators

open access: yesJournal of King Saud University: Engineering Sciences, 2019
This study uses bibliometric analysis techniques to provide an overview of the research conducted in the condition based maintenance (CBM) sciences. The paper objective is to determine the most influential research that has been conducted in this field ...
Mohammed A. Noman   +3 more
doaj   +1 more source

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