Results 111 to 120 of about 25,178,133 (232)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

VALUE OF INFORMATION IN CONDITION BASED MAINTENANCE USING PROPORTIONAL HAZARDS MODELS: A COMPARISON OF MAINTENANCE STRATEGIES

open access: yes, 2016
In this study, a comparison of equipment maintenance strategies’ cost behaviour is performed under different assumptions regarding equipment failure behaviour, availability of condition monitoring data, and its accuracy.
Farhang Doost, Seyed Alireza
core  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Deep Reinforcement Learning for Condition Based Monitoring in Aircraft Planning

open access: yes, 2019
Dissertação de Mestrado em Engenharia Informática apresentada à Faculdade de Ciências e TecnologiaAtualmente, as manutenções na aviação são maioritariamente pré-programadas ou reactivas.
Ferreira, Pedro Filipe Soares
core  

Prediction cost maintenance model of office building based on condition-based maintenance [PDF]

open access: yes, 2014
Building maintenance costs are continuously increasing as a result of poor maintenance. Consequently, there is an urgent need to develop solutions to reduce the maintenance costs.
Au-Yong, C.P., Ahmad, F., Ali, A.S.
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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