Results 111 to 120 of about 1,886,076 (260)
Estimating the cost of offshore maintenance and the benefit from condition monitoring [PDF]
The EU generally, and the UK, Belgium, Netherlands and Germany specifically, have ambitious plans for the large scale installation of offshore wind-power capacity.
Feuchtwang, Julian, Infield, David
core
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Reset Aviation Maintenance Program Study of U.S. Army Aviation [PDF]
U.S. Army helicopter maintenance condition is affected by operation environment and high flight hours. Due to the environmental conditions and high operation tempo of Afghanistan and Iraq, U.S. Army Aviation created the RESET aviation maintenance program
Williams, Kristopher B.
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Structural Health Monitoring of Composite Airframe [PDF]
Seminario impartido por el Profesor Aliabadi para describir los últimos logros obtenidos en el seno de los grupos de investigación que dirige en el Imperial College de Londres.Design and maintenance of future airframe composite structures is mainly ...
Aliabadi, Ferri M.H.
core
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Condition-Based Maintenance with Reinforcement Learning for Dry Gas Pipeline Subject to Internal Corrosion. [PDF]
Mahmoodzadeh Z +3 more
europepmc +1 more source

