Results 61 to 70 of about 509,143 (261)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Rail Weld Defect Prediction and Related Condition-Based Maintenance
IEEE Access, 2020 Rail weld defects are major threats to railroad transportation. Enormous resources have been required for related maintenance. This paper presents a creative solution to predict weld defects and to classify railroads into different conditions based on ...
Nan Yao, Yuejun Jia, Kai Tao
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Typology of condition based maintenance
Journal of Quality in Maintenance Engineering, 2011 PurposeThe purpose of this paper is the development of an empirically based typology of condition based maintenance (CBM) approaches, including the relevant characteristics and requirements.Design/methodology/approachAn exploratory case study was conducted in a major gas production facility.
Veldman, Jasper +2 more
openaire +4 more sources
A Context-Aware Oil Debris-Based Health Indicator for Wind Turbine Gearbox Condition Monitoring
Energies, 2019 One of the greatest challenges of optimising the correct operation of wind turbines is detecting the health status of their core components, such as gearboxes in particular.
Kerman López de Calle +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2015 Anomaly detection methods are becoming important for condition-based maintenance. This paper proposes an automatic creation method of extraction condition of sensor data for an anomaly detection system.
Tomoaki HIRUTA +2 more
doaj +1 more source