Results 81 to 90 of about 1,178,796 (218)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Ability of the Premise Condition Index to Identify Premises with Adult and Immature <i>Aedes</i> Mosquitoes in Kampong Cham, Cambodia. [PDF]

open access: yesAm J Trop Med Hyg, 2020
Hustedt J   +14 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Pathology findings and correlation with body condition index in stranded killer whales (Orcinus orca) in the northeastern Pacific and Hawaii from 2004 to 2013. [PDF]

open access: yesPLoS One, 2020
Raverty S   +20 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Risk Assessment Framework for Power Circuit Breakers Based on Condition, Replacement, and Criticality Indices

open access: yesEnergies
This paper develops a comprehensive framework for the risk assessment of 115 kV power circuit breakers (PCBs) by evaluating their condition, replacement needs, and criticality to the electrical network.
Suphon Kumpalavalee   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

EVALUASI JEMBATAN DI SUNGAI BOYONG YOGYAKARTA PASCA ERUPSI GUNUNG MERAPI 2010

open access: yesEmara: Indonesian Journal of Architecture, 2015
Mount Merapi is one of 129 active volcanoes in Indonesia with high frequent of eruptions. The 2010 Mount Merapi eruption on October 26th was the biggest disaster compare to similar disasters in the five previous period before.
Mega Ayundya Widiastuti
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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