Results 121 to 130 of about 942 (157)

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu   +8 more
wiley   +1 more source

SMART accelerates rate of cognitive gains in service members with mTBI and PTSD. [PDF]

open access: yesFront Hum Neurosci
Venza E   +7 more
europepmc   +1 more source

A Comparison of Regional Decisions for Doses and Administrations of New Drugs: Concordance, Discordance, and Dependencies

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Regional differences in approved drug dosages and administration are shaped by complex factors, including clinical data, prior regulatory decisions, and region‐specific considerations. This study investigated how such factors are associated with variations in approved doses across the United States Food and Drug Administration (FDA), European Medicines
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

Environmental Dynamism and Supply Chain Responsiveness Nexus: Do Organisational Improvisation and Supply Chain Orientation Matter?

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The crucial role of environmental dynamism (ED) in achieving supply chain responsiveness (SCR) has become a controversial topic in extant literature. However, despite several empirical studies on environmental dynamism and supply chain responsiveness, inconsistent findings and underexplored areas leave supply chain managers less informed about
Alexander Otchere Fianko   +3 more
wiley   +1 more source

Active and passive explicit instruction in question‐formulating in higher education

open access: yesThe Curriculum Journal, EarlyView.
Abstract We investigated the impact of explicit instruction on students' question‐formulating skill using a quantitative pre–post design. Surveys were administered to 291 undergraduates from two colleges before and after a dedicated lesson on question formulation. Students' skills were assessed through performance tasks, evaluated with both Bloom's and
Irit Sasson, Sigal Tifferet
wiley   +1 more source

Palliative Care for Patients with Severe Chronic Lung Diseases: A Swiss Position Paper.

open access: yesRespiration
Guler SA   +7 more
europepmc   +1 more source

Random finite element analysis on ground subsidence caused by tunnel excavation in karst regions with spatial variable soil

open access: yesDeep Underground Science and Engineering, EarlyView.
This study investigates ground subsidence during tunnel excavation in karst areas, highlighting the combined effects of karst cave proximity, cave size, and soil spatial variability. Findings suggest that shorter cave distances and larger cave sizes increase subsidence variability, and a modified Peck formula is proposed for more accurate subsidence ...
Zhenghong Su   +4 more
wiley   +1 more source

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