Results 61 to 70 of about 942 (157)

Multi‐modal integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes

Arthritis &Rheumatology, Accepted Article.
Summary Background Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease characterized by clinical and molecular heterogeneity, notably in the presence of anti‐cyclic citrullinated peptide antibodies (CCP). CCP‐positive (CCP+) RA patients exhibit more severe disease progression and distinct treatment responses compared to CCP‐negative (CCP ...
Javad Rahimikollu, Priyamvada Guha Roy, Akash Kishore, Danica Morgan Lee, Lauren A Vanderlinden, Kiran Nazarali, Fan Zhang, Dana P Ascherman, Daniella M Schwartz, Larry Moreland, Jishnu Das   +10 more
wiley   +1 more source

Head Growth Trajectories During the First Year of Life and Risk of Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Atypical infant head circumference (HC)—including increased rates of macrocephaly and microcephaly—has been linked to autism spectrum disorder (ASD). However, specific head growth trajectories associated with ASD remain poorly defined. This retrospective case–control study aimed to delineate these trajectories and examine their relationship to
Rewaa Balaum, Leena Elbedour, Einav Alhozyel, Gal Meiri, Dikla Zigdon, Analya Michaelovski, Orly Kerub, Idan Menashe   +7 more
wiley   +1 more source

ToM2: Parental Perception of Theory of Mind Abilities in Autistic Children

Autism Research, EarlyView.
ABSTRACT Understanding how parents perceive their children's abilities is crucial for family dynamics and intervention strategies, particularly in autism, where accurate parental assessment of social‐cognitive capabilities can influence support approaches and developmental outcomes. This study introduces ToM2, a novel measure examining parents' ability
Liraz Sasportas Joseph, Michal Perez, Anat Perry, Judah Koller   +3 more
wiley   +1 more source

Urban–Rural Differences and Sex‐Specific Cognitive Effects on Autism Symptom Trajectories: A Longitudinal Study of Autistic Children in Taiwan

Autism Research, EarlyView.
ABSTRACT Few longitudinal studies have mapped autism symptom trajectories outside Western contexts. This study aimed to characterize trajectories of autism symptoms, assessed using the Autism Diagnostic Observation Schedule (ADOS), and associated child and family factors among autistic children from two regions in Taiwan that differ by urbanicity ...
Yun‐Ju Chen, Hsiang‐Yuan Lin, Ching‐Lin Chu, Chin‐Chin Wu, Tzu‐Ling Lin, Hsing‐Chang Ni, Jiun‐Horng Liu, Yuh‐Ming Hou, Chung‐Hsin Chiang   +8 more
wiley   +1 more source

Population pharmacokinetics and exposure–response analysis of durvalumab in patients with resectable stage II to IIIB (N2) NSCLC in the phase III AEGEAN study

British Journal of Clinical Pharmacology, EarlyView.
Aims In the AEGEAN study, perioperative durvalumab plus platinum‐based neoadjuvant chemotherapy for patients with resectable stage II to IIIB (N2) non‐small‐cell lung cancer (NSCLC) demonstrated a favourable benefit–risk profile. This study evaluated population pharmacokinetics (PopPK) and exposure–response (ER) relationships of durvalumab in patients ...
Xiaoying Zhao, Junjie Ding, Jiajia Zhao, Ling Zhang, Aburough Abegesah, Yu‐qian Zhang, Cathy O'Brien, Gary J. Doherty, Allen C. Chen, KyoungSoo Lim, Song Ren, Peiming Ma, Diansong Zhou   +12 more
wiley   +1 more source

When nonstandard meets standard: Language and affective dynamics in accent-diverse group interactions. [PDF]

PLoS One
Lin M, Ramírez-Esparza N, Paxton A.
europepmc   +1 more source

Impact of extended insurance coverage on survival outcomes among patients with metastatic colorectal cancer in Taiwan

British Journal of Clinical Pharmacology, EarlyView.
Aims Predetermined treatment duration limits (PTDLs) are often used by Taiwan's National Health Insurance Administration to contain healthcare costs, but they may compromise patient outcomes. Therefore, we studied Taiwan's 2017 extension of the bevacizumab PTDL from 24 to 36 weeks in metastatic colorectal cancer (mCRC) to evaluate whether prolonged ...
Wei‐Ming Huang, Chen‐Han Chueh, Chien‐Yu Tseng, Christopher N. Kaufmann, Earl J. Morris, Chiao‐En Wu, Yi‐Wen Tsai   +6 more
wiley   +1 more source

Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection

British Journal of Clinical Pharmacology, EarlyView.
Background and Aim The rise of drug‐resistant tuberculosis (TB) poses a need for new drugs and combinations. TBAJ‐587, a new diarylquinoline (DARQ), has shown promising efficacy in preclinical studies. This work aimed to describe the pharmacokinetics (PK) of TBAJ‐587 and its metabolites M2 and M3 after single ascending dosing in healthy volunteers and ...
Albin A. M. Leding, Paul Bruinenberg, Almari Conradie, Jerry Nedelman, Antonio Lombardi, Dean Hickman, Ulrika S. H. Simonsson   +6 more
wiley   +1 more source

Priming Adjuncts in Sentence and Discourse Production in Neurotypical Adults and Persons With Aphasia. [PDF]

J Speech Lang Hear Res
Zhang P, Lee J.
europepmc   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source