Results 91 to 100 of about 1,795,209 (281)
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, EarlyView.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
The King and Ace Puzzle: A Proposal of Solution from a Term Logic
ProfilWhat I call the ‘king and ace puzzle’ here is an inference whose correct conclusion is hard to infer for people. There are reasoning theories offering explanations about this fact, including relevant frameworks such as the mental logic theory and the ...
Miguel López-Astroga
doaj +1 more source
Mutual fund performance in changing economic conditions: Evidence from an emerging economy
Cogent Economics & Finance, 2019 Traditional measures of assessment of mutual fund performance (alpha) are based mostly on Capital Assets Pricing Model which presupposes fixed sensitivity of risk exposure of a fund to its market proxy (beta).
Pankaj K Agarwal, H. K. Pradhan
doaj +1 more source
The conditional particle ka in Waama.pdf
Studies in African Linguistics, 1991 The particle ka in Waama has an underlying conditional function, and serves most frequently to set up possible worlds in the minds of interlocutors. By virtue of its function as a conditional, it can also mark topics.
Jennifer Rowe
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RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
Robust errant beam prognostics with conditional modeling for particle accelerators
Machine Learning: Science and TechnologyParticle accelerators are complex and comprise thousands of components, with many pieces of equipment running at their peak power. Consequently, they can fault and abort operations for numerous reasons, lowering efficiency and science output.
Kishansingh Rajput +7 more
doaj +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Frontiers in Immunology, 2017 Conditional and inducible Cre-loxP systems are used to target gene deletion to specific cell lineages and tissues through promoter-restricted expression of the bacterial DNA recombinase, Cre.
Alexandra L. McCubbrey +6 more
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Architectural Research Quarterly, 2012 Invited letter to ARQ reflecting on the challenges in describing a rural vernacular for contemporary housing with specific reference to Scottish ...
openaire +2 more sources
Heuristically Adaptive Diffusion‐Model Evolutionary Strategy
Advanced Science, EarlyView.Building on the mathematical equivalence between diffusion models and evolutionary algorithms, researchers demonstrate unprecedented control over evolutionary optimization through conditional diffusion. By training diffusion models to associate parameters with specific traits, they can guide evolution toward solutions exhibiting desired behaviors ...
Benedikt Hartl +3 more
wiley +1 more source