Results 121 to 130 of about 472,832 (312)
Advanced Science, EarlyView.Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang +16 more
wiley +1 more source
Replication package for: Conditional Superior Predictive Ability
, 2021 Jia Li, Zhipeng Liao, Rogier Quaedvlieg
openalex +2 more sources
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
Logo in Makista: irrealis and beyond
Journal of Ibero-Romance Creoles, 2019 Makista is endogenous to Macau and belongs to the Asian group of Portuguese-lexified creoles. Academic works have highlighted several close similarities to the Malacca Portuguese Creole (Kristang), and Batavia and Tugu Portuguese Creole, as well as ...
Mário Pinharanda Nunes
doaj
Conditional Toggle Mappings: Principles and Applications
, 2013 Santiago Velasco-Forero +2 more
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Advanced Science, EarlyView.Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang +9 more
wiley +1 more source
Generating probabilistic forecasts from arbitrary point forecasts using a conditional invertible neural network [PDF]
Kaleb Phipps +5 more
openalex +1 more source
Means of expressing conditional and semblance by jako by and jakoby [PDF]
, 2018 Martin Janečka
openalex +1 more source
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source