Results 211 to 220 of about 472,832 (312)

Fatigue as a moderator in symptom networks of insomnia, anxiety, and depression: insights from moderated network analysis. [PDF]

Front Psychiatry
Xing H, Ma X, Meng F, Li Z.
europepmc   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Beyond reweighting: On the predictive role of covariate shift in effect generalization. [PDF]

Proc Natl Acad Sci U S A
Jin Y, Egami N, Rothenhäusler D.
europepmc   +1 more source

Respiratory conditions

Journal of Physiotherapy
Sonia, Cheng, Mark R, Elkins
openaire   +2 more sources

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Medical education and abortion care: evaluating an interdisciplinary learning module in Germany. [PDF]

Arch Gynecol Obstet
Killinger K, Foerstel M, Wallwiener S.
europepmc   +1 more source

Conditional probabilities of QTL genotypes given marker genotypes in a natural population.

, 2015
Linghua Zhou, Yong Shen, Jiang Libo, Yin Danni, Guo Jingxin, Hui Zheng, Sun Hao, Rongling Wu, Yunqian Guo   +8 more
openalex   +2 more sources

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Conditional UNet emulation of CMAQ simulations for fine particulate matter concentration prediction. [PDF]

Sci Rep
Lee Y, Park J, Kim J, Woo JH, Lee JH.
europepmc   +1 more source