Results 121 to 130 of about 153,987 (282)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

A Novel Recognition Strategy for Epilepsy EEG Signals Based on Conditional Entropy of Ordinal Patterns. [PDF]

Entropy (Basel), 2020
Liu X, Fu Z.
europepmc   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Bivariate entropy-transformed Weibull distribution for modelling bivariate system-simulated data from a computer series: Mathematical features and applied results

Alexandria Engineering Journal
The bivariate FGM Entropy-Transformed model is a new, flexible family of generalized bivariate distributions based on the FGM copula. The bivariate FGM Entropy-Transformed Weibull model is a new model that we developed based on the FGM copula and Entropy-
Tabassum Naz Sindhu, Abdon Atangana, Muhammad Bilal Riaz, Tahani A. Abushal   +3 more
doaj   +1 more source

An Efficient, Parallelized Algorithm for Optimal Conditional Entropy-Based Feature Selection. [PDF]

Entropy (Basel), 2020
Estrela G, Gubitoso MD, Ferreira CE, Barrera J, Reis MS.   +4 more
europepmc   +1 more source

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

Advanced Science, EarlyView.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu, Yihan Wang, Haiyun Chen, Xinye Yu, Tingyu Wang, Yajing Weng, Meihong Guo, Ying Huang, Gaojian Tao, Wangsen Cao, Yong Wang, Daojuan Wang   +11 more
wiley   +1 more source

Statistical measure of dispersity in complex weighted networks of low temperature plasma chemistry

Journal of Physics: Complexity
A chemical reaction system is frequently complex when its molecular species are excited by high-energy external sources. Here we examine molecular (SiH _4 ) plasma chemistry in which high-energy electrons dissociate, decompose and polymerize many ...
Kota Hamano, Shigeyuki Miyagi, Tomoyuki Murakami, Tsuyohito Ito, Osamu Sakai   +4 more
doaj   +1 more source

Question on Conditional Entropy

, 2007
The problems of conditional entropy's definition and the formula to compute conditional entropy are analyzed from various perspectives, and the corrected computing formula is presented. Examples are given to prove the conclusion that conditional entropy never be increased is not absolute, thus the representation that information is to decrease ...
openaire   +2 more sources

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

Advanced Science, EarlyView.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao   +10 more
wiley   +1 more source