Results 51 to 60 of about 503,210 (300)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Fake Perfect in X-marked Conditionals

Semantics and Linguistic Theory, 2017
The topic of this paper is a problem concerning the interpretation of tense in conditionals: Fake Tense. Fake Tense refers to the observation that in English subjunctive conditionals the Simple Past, and sometimes also the Past Perfect, appear not to be interpreted as semantic past tense or past perfect.
openaire   +3 more sources

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

Neccessary Condition for Odd Perfect Number

, 2022
Abstract if a integer being odd perfect number we get inequality between the number and the square of number of its divisors.
openaire   +1 more source

Machine Learning for Designing Perovskites and Perovskite‐Inspired Solar Materials: Emerging Opportunities and Challenges

Advanced Science, EarlyView.
This review offers a comprehensive comparison between perovskites and perovskite‐inspired materials (PIMs), focusing on their crystal structures, electronic properties, and chemical compositions. It evaluates the applicability of machine learning (ML) descriptors and models across both material classes.
Yangfan Zhang, Yiming Xia, Ali Shakiba, Hongrui Zhang, Xiaojing Hao, Priyank V. Kumar, Mahesh P. Suryawanshi   +6 more
wiley   +1 more source

Deontic logic as a study of conditions of rationality in norm-related activities [PDF]

, 2016
The program put forward in von Wright's last works defines deontic logic as ``a study of conditions which must be satisfied in rational norm-giving activity'' and thus introduces the perspective of logical pragmatics.
Žarnić, Berislav
core  

Perfectionism and burnout in canoe polo and kayak slalom athletes: The mediating influence of validation and growth-seeking [PDF]

, 2010
Recent research suggests that validation-seeking and dimensions of perfectionism may be antecedents of athlete burnout. The present investigation examined whether validation and growth-seeking mediate the relationship between selforiented and socially ...
Appleton, PR, Hall, HK, Hill, AP, Murray, JJ   +3 more
core   +1 more source

Did the Indian Green Revolution Change the Farm Size–Productivity Relationship?

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We examine the relationship between farm size and productivity during India's Green Revolution, a period of rapid technological transformation. Using a unique panel of over 5000 Indian farm households that spans the Green Revolution (1971–1999), we show that the classic (linear) inverse farm size–productivity relationship gradually evolved ...
Rabail Chandio, Leah E. M. Bevis
wiley   +1 more source

On the use of testability measures for dependability assessment [PDF]

, 1996
Program “testability” is informally, the probability that a program will fail under test if it contains at least one fault. When a dependability assessment has to be derived from the observation of a series of failure free test executions (a common need ...
Bertolino, A., Strigini, L.
core   +1 more source

Foreign labor, peer‐networking and agricultural efficiency in the Italian dairy sector

Agribusiness, EarlyView.
Abstract While the presence of immigrants in the agricultural sector is widely acknowledged, the empirical evidence on its economic consequences is lacking, especially from a microeconomic perspective. Using the Farm Accountancy Data Network panel data for Italian dairy farms in the period 2008–2018, the present study investigates the relationship ...
Federico Antonioli, Simone Severini, Mauro Vigani   +2 more
wiley   +1 more source