Results 101 to 110 of about 438,874 (275)
Advanced Science, EarlyView.This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley +1 more source
Learnable Diffusion Framework for Mouse V1 Neural Decoding
Advanced Science, EarlyView.We introduce Sensorium‐Viz, a diffusion‐based framework for reconstructing high‐fidelity visual stimuli from mouse primary visual cortex activity. By integrating a novel spatial embedding module with a Diffusion Transformer (DiT) and a synthetic‐response augmentation strategy, our model outperforms state‐of‐the‐art fMRI‐based baselines, enabling robust
Kaiwen Deng +2 more
wiley +1 more source
Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems
Advanced Science, EarlyView.Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen +8 more
wiley +1 more source
Generalized Exponentiated Moment Exponential Distribution [PDF]
, 2014 Moment distributions have a vital role in mathematics and statistics, in particular in probability theory, in the perspective research related to ecology, reliability, biomedical field, econometrics, survey sampling and in life-testing.
Ahmad, Munir +4 more
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun +13 more
wiley +1 more source
Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source
Diffusion–Model–Driven Discovery of Ferroelectrics for Photocurrent Applications
Advanced Science, EarlyView.We developed a diffusion model–based generative AI and high‐throughput screening framework that accelerates the discovery of photovoltaic ferroelectrics. By coupling AI driven crystal generation with machine learning and DFT screening, we identified Ca3P2 and LiCdP as new ferroelectric materials exhibiting strong polarization, feasible switching ...
Byung Chul Yeo +3 more
wiley +1 more source
Reliability Analysis Method of Rotating Machinery Based on Conditional Random Field. [PDF]
Comput Intell Neurosci, 2022 Zheng H, Qiao X.
europepmc +1 more source
Equivalent Mixing Conditions for Random Fields
The Annals of Probability, 1993 Let \(X_ t\), \(t \in R^ d\), \(d \geq 2\), be a strictly stationary random field, \(\| t \|\) be a Euclidean norm in \(R^ d\), \[ \alpha({\mathcal A},{\mathcal B})=\sup | P(AB)-P(A) P(B) |,\quad A \in {\mathcal A},B \in {\mathcal B}, \] \[ \rho({\mathcal A},{\mathcal B})=\sup | \text{corr} (V,W) |,\quad V \in {\mathcal L}_ 2({\mathcal A}),\;W \in ...
openaire +2 more sources