Results 71 to 80 of about 3,593 (265)

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger   +7 more
wiley   +1 more source

Engineering Layered Magnetic Hydrogels for Cell Placement via Shear and Magnetic Field‐Induced Assembly

Advanced Materials, EarlyView.
Magnetic particles are organized into layered architectures by combining shear flow and magnetic fields, with the resulting structures governed by appropriate Mason numbers. The programmed assemblies provide spatial guidance for cell placement, linking field‐controlled self‐assembly, flow‐induced structuring and biological organization.
Guillermo Camacho, Jose R. Morillas, Jesús García‐Gutiérrez, Stefania Nardecchia, Óscar Martínez‐Cano, Juan de Vicente   +5 more
wiley   +1 more source

Condicionalidad en una Unión de Derecho: el Mecanismo Europeo de Estabilidad (MEDE)

Revista Vasca de Administración Pública, 2018
This article analyses the application of conditionality within the European Stability Mechanism (ESM) from the perspective of the fundamental rights recognized within the EU.
Ferran Armengol Ferrer
doaj   +1 more source

Elements of Comparison and Synthesis / Chapter 6 of Europeanization and Conflict Resolution: Case Studies from the European Periphery [PDF]

Journal on Ethnopolitics and Minority Issues in Europe, 2004
This last chapter is a summary of main ideas developed in the rest of the study, with emphasis on setting out the analytical approach, comparisons of the four case studies, and some general observations that result from the comparisons.
Gergana Noutcheva, Tamara Kovziridze, Michel Huysseune, Bruno Coppieters, Marius Vahl, Michael Emerson, Nathalie Tocci   +6 more
doaj  

Decoupling Activation and Preservation: Architectural Design Principles of Organic Frameworks for Selective Photocatalytic Methane Oxidation

Advanced Materials, EarlyView.
Selective methane (CH4) photooxidation emerges from architectural decoupling of activation and preservation. Programmable organic semiconductor frameworks spatially organize oxidative flux and intermediate residence, separating reaction zones from product domains to synchronize activation strength with stabilization and establish a selective oxidation ...
Minxian Zhang, Jie He, Jinqiang Zhang, Hongqi Sun, Shaobin Wang, Xiaoguang Duan   +5 more
wiley   +1 more source

Conditionality in the EU Accession Process: From a Normative Daydream to the Implementation Realities [PDF]

Međunarodni Problemi
Enlargement conditionality is a cornerstone of the European Union (EU) accession process, serving as a powerful tool despite its notable inherent limitations.
Uroš Ćemalović, Milica Ilić
doaj   +1 more source

Mechanistically Interpretable Artificial Intelligence for Designing Oxygen Electrocatalysts

Advanced Materials, EarlyView.
Mechanistically interpretable artificial intelligence screens nearly seven million perovskite compositions and identifies key descriptors—d‐p hybridization and densification resistance—that govern oxygen electrocatalysis. The discovered BaCo0.8Nb0.1Zr0.1O3‐δ achieves a record 2.68 W cm−2 peak power density at 600°C with over 500 h of durable operation ...
Xueyu Hu, Yucun Zhou, Haoyu Li, Zheyu Luo, Nai Shi, Yong Ding, Weining Wang, Weilin Zhang, Doyeub Kim, Chanho Kim, Yoojin Ahn, Nikhil Govindarajan, Minda Zou, Zhijun Liu, Yuefeng Song, Meilin Liu   +15 more
wiley   +1 more source

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

The european integration impact on the europeanization of public administration in Ukraine

Aspekti Publìčnogo Upravlìnnâ, 2013
The impact of European integration on the Europeanization of public administration in Ukraine is considered. By means of a proposed criterion for the presence of conditionality elements in EU – Ukraine relations the basic tools of the influence is ...
Nadiia Mykhailivnа Rudik
doaj   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source