Results 91 to 100 of about 7,482,658 (287)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review

Stem Cell Research & Therapy
Introduction Mesenchymal stem cell (MSC)-derived conditioned media is emerging as a promising alternative to stem cell therapy, owing to its abundant content of growth factors and cytokines.
Sona Zare, Alireza Jafarzadeh, Solmaz Zare, Amir Shamloo   +3 more
doaj   +1 more source

Gut Bacteria of Water Monitor Lizard (Varanus salvator) Are a Potential Source of Antibacterial Compound(s)

Antibiotics, 2019
For the past few decades, there has been limited progress in the development of novel antibacterials. Previously, we postulated that the gut microbiota of animals residing in polluted environments are a forthcoming supply of antibacterials. Among various
Noor Akbar, Ruqaiyyah Siddiqui, K Sagathevan, Mazhar Iqbal, Naveed Ahmed Khan   +4 more
doaj   +1 more source

Purity Determines the Effect of Extracellular Vesicles Derived from Mesenchymal Stromal Cells

Cells, 2020
Extracellular vesicles (EVs) have been recently identified as vital components of cell-based therapies based on the observation that conditioned media from cultured stromal cells reproduce some of the beneficial effects of intact cells.
Maria Antònia Forteza-Genestra, Miquel Antich-Rosselló, Javier Calvo, Antoni Gayà, Marta Monjo, Joana Maria Ramis   +5 more
doaj   +1 more source

Exposure to polybrominated diphenyl ethers (PBDEs) suppresses the release of pro-inflammatory products by alveolar macrophages in vitro [PDF]

, 2010
Endocrine disrupting chemicals have adverse effects on immune function that may result in respiratory conditions. Inhalation of dust is a major route of exposure to PBDEs; however, the impact of PBDEs on the immune response is unclear.
Hennigar, Stephen R
core   +1 more source

A bioprinted cardiac patch composed of cardiac-specific extracellular matrix and progenitor cells for heart repair [PDF]

, 2018
Congenital heart defects are present in 8 of 1000 newborns and palliative surgical therapy has increased survival. Despite improved outcomes, many children develop reduced cardiac function and heart failure requiring transplantation.
Bejleri, Donald, Brown, Milton E., Christman, Karen L., Davis, Michael E., Gaetani, Roberto, Nachlas, Aline L. Y., Streeter, Benjamin W.   +6 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mapping the lipidomic secretome of the early equine embryo

Frontiers in Veterinary Science
The lipidomic secretions of embryos provide a unique opportunity to examine the cellular processes of the early conceptus. In this study we profiled lipids released by the early equine conceptus, using high-resolution mass spectrometry to detect ...
Edwina F. Lawson, Russell Pickford, Robert John Aitken, Zamira Gibb, Christopher G. Grupen, Aleona Swegen   +5 more
doaj   +1 more source

Enhanced formation of giant cells in common variable immunodeficiency: Relation to granulomatous disease. [PDF]

, 2017
Peripheral monocytes from patients with common variable immunodeficiency (CVID) had on average a 2 fold greater tendency to form giant cells in medium without additional cytokines. Giant cell formation was faster and 3 to 5 fold higher in most CVID cells
Ardeniz, Aukrust, Aukrust, Ballow, Barbosa, Barnard, Bates, Bayry, Bayry, Bear, Bentley, Brincker, Byrd, Cambronero, Cohen, Conley, Cunningham-Rundles, David A. Webster, de Waal, Dugast, El-Zammar, Fais, Farber, Fevang, Fiedler, Grunewald, Heresbach, Holm, Karen Whiting, Kasahara, Kirkpatrick, Knight, Kornacker, Kreipe, Kurata, Lin, Ling, Marashi, McQuaid, Mizuno, Most, Most, Mullighan, Pearl, Postlethwaite, Rissoan, Ruth Pettengell, Scott-Taylor, Scott-Taylor, Segal, Sewell, Thatayatikom, Timothy H. Scott-Taylor, Wahlstrom, Webster, Wells, Yong, Zielen   +57 more
core   +1 more source

The effects of conditioned media generated by polarized macrophages on the cellular behaviours of bone marrow mesenchymal stem cells

Journal of Cellular and Molecular Medicine, 2017
Macrophages (Mφs) are involved in a variety of physiological and pathological events including wound healing and tissue regeneration, in which they play both positive and negative roles depending on their polarization state.
Xiao-Tao He, Xuan Li, Yuan Yin, R. Wu, Xin-Yue Xu, Faming Chen   +5 more
semanticscholar   +1 more source