Results 141 to 150 of about 249,882 (306)

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

THE PSYCHOLOGICAL IMPACT OF PUNISHMENT ON ANDREW NEIMAN IN THE WHIPLASH MOVIE: OPERANT CONDITIONING APPROACH

Frasa
A person's behavior can be studied using the Operant Conditioning method with one of its main concepts, namely punishment. Giving punishment to individuals will cause a significant impact. This research examines the impact of punishment on Andrew Neiman'
Alfi Nur Kholilia, Diyah Fitri Wulandari
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

METODE DAKWAH DALAM MEMBENTUK AKHLAK MAHMUDAH REMAJA

Wardah, 2015
Virtue is a psychological phenomenon that permeates the soul, actions arising from it easily, without using it first consideration. If that appears good deeds and praise by reason and Personality 'is called with good morals (mahmudah). Conversely, if the
Nurseri Hasnah Nasution
doaj  

Effects of perceived control on thermal response and cooling carbon emissions across different operation modes

Scientific Reports
Human psychological adaptation to indoor thermal conditions, particularly through perceived control, is increasingly recognized for its potential to influence building energy consumption. Despite this, its quantifiable impact remains unexplored. Here, we
Dongyu Lu, Haiyan Yan, Guodong Yuan, Hui Zhang, David Chow, Lihua Zhao   +5 more
doaj   +1 more source

Interoceptive awareness and unaware fear conditioning: are subliminal conditioning effects influenced by the manipulation of visceral self-perception? [PDF]

, 2011
An K. Raes, Barrett, Bechara, Bliss-Moreau, Bliss-Moreau, Cisler, Clark, Clark, Craig, Critchley, Critchley, Custers, Dawson, Domschke, Eitam, Fifer, Fox, Greenwald, Junge, Katkin, Khalsa, Klucken, Knight, Knight, Koster, Koster, Koster, Lipp, Lovibond, Lundqvist, Mitchell, Mowrer, Ohman, Olsson, Perruchet, Perruchet, Pollatos, Posner, Purkis, Raes, Rudi De Raedt, Schultz, Smith, Spielberger, Tabbert, Tabbert, Van Boxtel, Van Damme, Vuilleumier, Weidemann, Weike, Wiens, Yiend   +52 more
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source