Results 171 to 180 of about 5,357,439 (379)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Evaluación del potencial reproductivo del chorito (Mytilus chilensis) de dos poblaciones naturales sometidas a diferentes temperaturas de acondicionamiento Assessment of the reproductive potential of the mussel (Mytilus chilensis) from two natural populations subjected to different conditioning temperatures

open access: yesLatin American Journal of Aquatic Research, 2012
Mytilus chilensis tiene ciclos reproductivos que varían latitudinalmente. Presenta reducida diferenciación genética y morfológica debido a un gran potencial de dispersión.
Luis Lagos, Iker Uriarte, Gabriel Yany
doaj  

CoSe-Co: Text Conditioned Generative CommonSense Contextualizer [PDF]

open access: hybrid, 2022
Rachit Bansal   +4 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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